Differential Validity, Differential Prediction,and College Admission Testing: A Comprehensive Review and Analysis

The objective of this prospective investigation was to compare the performance of OSNA with both standard hematoxylin and eosin analysis and intensive histopathology in the detection of colon cancer lymph node metastases.

Abstract

OSNA appeared to be a powerful and promising molecular tool for the detection of lymph node metastases in patients with colon cancer. OSNA had similar performance in the detection of lymph node metastases compared with intensive histopathologic investigations and appeared to be superior to standard histology with H&E. Most important, the authors concluded that OSNA may lead to a potential upstaging of >15% of patients with colon cancer.