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The stereospecificity of the inositol receptor of the silkworm Bombyx mori

Brain ResearchPublished 1 October 1971Open access
William Jakinovich, Bernard W. Agranoff
Citations10
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TL;DR

The specificity of the ‘sugar-sensitive’ hair in the silkworm to the 9 isomers of myo -inositol was studied electrophysiologically and it was determined that the inositol receptor located in the Ss-I hair responded only to myo- and epi -inposol while allo -Inositol stimulated another receptor in the same hair.

Abstract

The specificity of the `sugar-sensitive' hair (Ss-I) in the silkworm to the 9 isomers of myo-inositol was studied electrophysiologically. Of the 9 isomers only myo-, epi- and allo-inositol receptor activity. Using various mixtures of these cyclitols and sucrose it was determined that the inositol receptor located in the Ss-I hair responded only to myo- and epi-inositol while allo-inositol stimulated another receptor in the same hair. Threshold and magnitude of response of this receptor were nearly the same for both cyclitols. Configurational specificity of the inositol receptor and its role in taste and lipid metabolism are discussed.

Keywords

Agricultural and Biological SciencesNeuroscience