The actions of ivermectin on cultured chick spinal cord neurons
Neuroscience LettersPublished 1 September 1986
Kinzo Matsumoto, Jun Yamazaki, Minako Kasuya, Hideomi Fukuda
Citations9
SJR quartileQ2
SJR score0.77
SNIP0.67
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TL;DR
Results suggest that IVM increases membrane conductance through sites which are different from GABA recognition sites, and this agent did not have any effects on either the actions of GABA agonists on neurons or [3H]GABA efflux from those cells.
Abstract
The effects of ivermectin (IVM) on cultured chick spinal neurons sensitive to GABA agonists were investigated. IVM caused a change of membrane potential which was associated with an increase in membrane conductance, apparently reversed at about -40 mV and weakened by repetitive application. Furthermore, this agent did not have any effects on either the actions of GABA agonists on neurons or [3H]GABA efflux from those cells. These results suggest that IVM increases membrane conductance through sites which are different from GABA recognition sites.
Keywords
PsychologyAgricultural and Biological SciencesNeuroscience
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