Androgens versus placebo or no treatment for idiopathic oligo/asthenospermia
Cochrane Database of Systematic ReviewsPublished 21 October 1996Open access
Patrick Vandekerckhove, Richard Lilford, Andy Vail, Edward G. Hughes
Citations28
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TL;DR
The objective of this review was to assess the effect of androgen treatment of men among couples where failure to conceive has been attributed to idiopathic oligo- and/or asthenospermia.
Abstract
There is not enough evidence to evaluate the use of androgens for male subfertility.[This abstract has been prepared centrally.].
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
BMJPopulation study of causes, treatment, and outcome of infertility.
1,143 Citations1985M.G.R. Hull, Cathryn Glazener +8 more
Infertility was unexplained in 28% and the chance of pregnancy was mainly determined by duration of infertility, and in vitro fertilisation could benefit 80% of cases of tubal damage and 25% of unexplained infertility--that is, 18% of all cases, representing up to 216 new cases each year per million of the total population.
BMJCase-control study of whether subfertility in men is familial
153 Citations1994Richard Lilford, A. Jones +3 more
Subfertility in men has a familial component, and the observations are consistent with an autosomal recessive mode of inheritance in over half the cases.
Fertility and SterilityComparison of the effectiveness of placebo, clomiphene citrate, mesterolone, pentoxifylline, and testosterone rebound therapy for the treatment of idiopathic oligospermia
132 Citations1983Christina Wang, Chi-Wing Chan +2 more
Treatment with the placebo, mesterolone, pentoxifylline, and testosterone rebound therapy did not result in a significant increase in the mean sperm concentration or pregnancy in the partners.
Fertility and SterilityEmpirical evidence of bias in infertility research: overestimation of treatment effect in crossover trials using pregnancy as the outcome measure
114 Citations1996Khalid S. Khan, Salim Daya +2 more
The use of a crossover design for evaluating infertility treatments with outcomes that prevent patients from completing later phases of the trial should be avoided because it leads to exaggerated estimates of treatment effect and may result in erroneous inferences and clinical decisions.
AndrologiaRecent Progress in Pharmacological Therapy of Male Subfertility - a Review*
77 Citations2009Wolf‐Bernhard Schill
Pharmakologische Therapie der Subfertilität des Mannes ist eine wirklich-physiologisch-konstruktivität beziehungsweise eine ganze politische Beziehungen zur Verfertigung von Krankheiten und Wirklichkeit.
International Journal of AndrologyMesterolone and idiopathic male infertility: a double‐blind study
62 Citations1989WORLD HEALTH ORGANIZATION TASK FORCE ON THE DIAGNOSIS AND TR INFERTILITY
There were no significant changes semen quality during the course of the study, apart from an increase in sperm concentration 3 months after the start of treatment, and the increase was greatest among the placebo treated group, but did not differ significantly between treatment groups.
Fertility and SterilityPlacebo-controlled trial of high-dose Mesterolone treatment of idiopathic male infertility
49 Citations1991Jan Gerris, Frank Comhaire +3 more
The findings cast doubt on the possible usefulness of high-dose Mesterolone treatment of idiopathic male infertility, although a significant increase in motility and in the proportion of spermatozoa with normal morphology was recorded in the Mesterolate-treated cases.
British Journal of UrologyRandomised Trial of Mesterolone versus Vitamin C for Male Infertility
46 Citations1984T. B. Hargreave, K. F. KYLE +7 more
Results indicate that mesterolone therapy given in the absence of any defined endocrinopathy is of no benefit in promoting male fertility and furthermore the authors have been unable to find any subgroup who will respond.
AndrologiaTreatment of Oligozoospermia with Tamoxifen (open and controlled studies)
44 Citations2009László Török
In the open study, tamoxifen treatment led to significant increases in the spermatozoa concentration and the total sperm count, but this could not be confirmed with the double‐blind set‐up.
AndrologiaOral Treatment of Oligozoospermia with Testosterone-Undecanoate: Results of a Double-Blind-Placebo-Controlled Trial/Orale Behandlung der Oligozoospermie mit Testosteronundecanoat: Ergebnisse einer Plazebokontrollierten Doppelblindstudie
41 Citations2009H. Pusch
Conventional spermograms were supplemented by extended morphologic analysis and motility determinations by laser‐Doppler‐spectroscopy and one randomized half of the patients received a placebo in a double blind manner.
Fertility and SterilityApparent Effect of Ascorbic Acid Medication on Semen Metal Levels
41 Citations1979William A. Harris, Thaddeus E. Harden +1 more
No apparent spermagglutination and restored fertility may be due to the interaction of ascorbic acid with cations found in semen, but significant increases in levels in semen following therapy could not be attributed to ascorBic acid alone, nor, similarly, the improved physical parameters of each subject's semen following Therapy.
Fertility and SterilityTestosterone Rebound Therapy: A Neglected Modality
37 Citations1978Charles W. Charny, Julian Gordon
Of 225 patients followed, 52% rebounded to fertile levels followed by pregnancy in the wives of 25% and no persistent azoospermia was observed.
International Journal of Gynecology & ObstetricsTreatment of idiopathic testicular failure with high‐dose testosterone undecanoate: A double‐blind pilot study
35 Citations1991F. Comhaire
This result demonstrates that the enhancing effect of peroxidation on sperm-zona adhesion involves a direct action on the properties of the sperm-plasma membrane, rather than an indirect consequence of acrosomal damage and acrosin leakage.
Fertility and SterilityTreatment of idiopathic testicular failure with high-dose testosterone undecanoate: a double-blind pilot study
34 Citations1990Frank Comhaire
It is concluded that high-dose T undecanoate is not effective in the treatment of men with infertility with idiopathic testicular failure.
AndrologiaDouble-Blind Cross over Treatment with Mesterolone and Placebo of Subfertile Oligozoospermic Men Value of Testicular Biopsy
25 Citations2009J. H. Aafjes, J. C. M. van der Vijver +2 more
Doppelblind‐cross over‐Studie einer Therapie mit Mesterolon von Männern mit Oligozoospermie und die Bedeutung der Hodenbiopsie.
British Journal of Clinical PharmacologyMesterolone: thrombosis during treatment, and a study of its prothrombotic effects.
22 Citations1979G.D.O. Lowe, J A Thomson +3 more
It is concluded that in a conventional dose taken for 3 weeks mesterolone does not produce a consistent measurable prothrombotic state, nor does it enhance fibrinolysis.
International Journal of Gynecology & ObstetricsThe effect of mesterolone on sperm count, on serum follicle stimulating hormone, luteinizing hormone, plasma testosterone and outcome in idiopathic oligospermic men
15 Citations1988T.R. Varma, Reena Patel
Mesterolone was found to be more useful in patients with a sperm count ranging between 5 and 20 million/ml and those with severe oligospermia (count <5 million) do not seem to benefit from this therapy.
Clinical EndocrinologyTHE HORMONE RESPONSE TO A SYNTHETIC ANDROGEN (MESTEROLONE) IN OLIGOSPERMIA
13 Citations1977F. R. Jackaman, I. D. Ansell +4 more
The sperm concentration showed a variable response to treatment, and the analysis of variance of sperm concentration and motility for the periods before and after treatment, for all the patients, showed no significant difference in the sperm concentration.
AndrologiaThe Medical Treatment of Male Infertility
12 Citations2009Ahmed Ibrahim, Z.G. HAYAT
Medikamentöse Behandlung der Infertilität des Mannes ist unterschiedlich gegenüber dem Institut für Wirklichkeit, dessen Forschung beziehungsweise Erfahrung erfahren ist übersetzt.
International Urology and NephrologyMesterolone treatment of patients with pathospermia
10 Citations1978János Szöllõsi, Gy. Falkay +1 more
The authors conclude that Mesterolone does not influence plasma FSH, LH and testosterone levels, it has only peripheral effects.
AndrologiaDer Einfluß eines synthetischen Androgens (Mesterolon) auf die Samenqualität
7 Citations2009B. Welker, E. W. Jecht +1 more
An 224 infertilen Patienten mit normalem und pathologischem Genitalbefund wurde die Wirkung der Einnahme von täglich 30, 60 mg Mesterolon (M) bei mindestens dreimonatiger Anwendung untersucht.
PubMed[The effect of a synthetic androgen (mesterolone) on semen quality].
4 Citations1983B. Welker, E. W. Jecht +1 more
According to the data, careful selection of patients for treatment with M. should be confined to patients with mild idiopathic oligo (astheno) zoospermia where no specific therapy - such as, e.g., high ligation for varicocele - is available.
Hormone ResearchGonadotrophin Suppression by the Synthetic Androgen Mesterolone in Idiopathic Oligospermia
3 Citations2008R. K. Bhathena, Devangi Patel
AndrologiaPlasma Cholesterol, Triglycerides, FSH and Testosterone Levels of Normolipemic Male Patients with Decreased Fertility Treated with Mesterolone
3 Citations2009V. Nikkanen
Cholesterin, Triglyzeride, FSH and Testosteron im Serum von normolipämischen Patienten mit eingeschränkter Fertilität nach Behandlung mit Mesterolon wurden gefunden.
Hormone and Metabolic ResearchEffect of Non Aromatizable Androgens on LHRH and TRH Responses in Primary Testicular Failure
3 Citations1984Irving M. Spitz, Ehud J. Margalioth +4 more
Assessment of the gonadotropin, TSH and PRL responses to the non aromatizable androgens, mesterolone and fluoxymestrone, in 27 patients with primary testicular failure found that basal LH, FSH and TSH levels, as well as gonadotropic responses to LHRH and T SH and PRl responses to TRH, were increased.
PubMedThe effects of mesterolone on sperm count in idiopathic oligospermia.
2 Citations1987R. K. Bhathena, Mehernosh J Jassawalla +1 more
Mesterolone was found to be effective in improving the sperm concentration in mild and moderate rather than in severe idiopathic oligospermia.
AndrologiaZur Behandlung von Fertilitätsstörungen des Mannes mit einer Kombination von Mesterolon und Kallikrein
2 Citations2009C. Schirren, B. HECKHOFF-HUETH
Bericht über die perorale Therapie von 73 Patienten mit Oligo‐, Astheno‐ and Teratozoospermie mittels einer Kombination aus Mesterolon and Kallikrein, werden gezeigt, daß die Spermatozoendichte insgesamt unbeeinflußt blieb.