Periconceptional folic acid containing multivitamin supplementation
European Journal of Obstetrics & Gynecology and Reproductive BiologyPublished 1 June 1998
Andrew E. Czeizel
Citations176
SJR quartileQ2
SJR score0.80
SNIP0.99
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TL;DR
A significant prevention of the first occurrence of neural-tube defect, urinary tract and cardiovascular defects and a decrease in the rate of limb deficiencies and congenital hypertrophic pyloric stenosis is found in the Hungarian double-blind placebo controlled randomised trial of periconceptional folic acid containing multivitamin and trace element supplementation.
Abstract
Consumption of foods which are rich in folate may not be the best way to prevent neural-tube defects and other congenital abnormalities. Periconceptional multivitamin supplementation is part of the periconceptional care in Hungary and it is an appropriate forum for the practical delivery for this primary prevention action. However, as a large proportion of pregnancies are unplanned, the widespread use of bread fortified with folic acid, vitamin B12 and B6 may decrease a considerable part of neural-tube defects and some other congenital abnormalities, in addition to vascular diseases due to hyperhomocysteinemia.
Keywords
Medicine
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