The Relationship between Neurophysin and the Soluble Proteins of Pituitary Neurosecretory Granules
Biochemical JournalPublished 1 July 1967Open access
Camin Dean, Morley D. Hollenberg, D. B. Hope
Citations36
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TL;DR
The polypeptide hormones, oxytocin and vaso- pressin, have been isolated from pituitary posterior lobes as a hormone-protein complex by several workers.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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The major component, neurophysin-M, was distinguished from the protein isolated by van Dyke by the presence of methionine and the absence of histidine, and binds both oxytocin and vasopressin with similar affinities.
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The mobility of each component is expressed as an RF value defined as the ratio of the distance moved by a particular component to that of the visible buffer boundary.
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