Genetic models of the transmission of affective disorders
Journal of Psychiatric ResearchPublished 1 December 1975
Elliot S. Gershon, Miron Baron, James F. Leckman
Citations83
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SJR score1.49
SNIP1.15
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Abstract
Multiple threshold models of inheritance of liability to semi-continuous traits are applied to data on affective and related disorders in relatives of 70 patients with bipolar or unipolar affective disorder, relatives of 75 normal controls, and population prevalence data. Unipolar and bipolar affective disorders and related affective disturbances are represented in the model at different thresholds on a single continuum of genetic-environmental liability. Neither a multifactorial inheritance or single major locus inheritance can be ruled out as a mode of transmission. The heritability of affective disorders appears to be greater than 0·.
Keywords
Neuroscience
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