Increase in Circulating Products of Lipid Peroxidation (F<sub>2</sub>-Isoprostanes) in Smokers — Smoking as a Cause of Oxidative Damage
New England Journal of MedicinePublished 4 May 1995Open access
J MORROW, Balz Frei, Atkinson W. Longmire, J. Michael Gaziano, Sean M. Lynch, Yu Shyr
Citations1,337
SJR quartileQ1
SJR score19.08
SNIP13.47
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The increased levels of F2-isoprostanes in the circulation of persons who smoke support the hypothesis that smoking can cause the oxidative modification of important biologic molecules in vivo.
Abstract
The increased levels of F2-isoprostanes in the circulation of persons who smoke support the hypothesis that smoking can cause the oxidative modification of important biologic molecules in vivo.
Keywords
ChemistryMedicineBiochemistry, Genetics and Molecular Biology
New England Journal of MedicineBeyond Cholesterol
6,420 Citations1989Franklin H. Epstein, Daniel Steinberg +4 more
New England Journal of MedicineVitamin E Consumption and the Risk of Coronary Heart Disease in Men
2,355 Citations1993Eric B. Rimm, Meir J. Stampfer +4 more
Evidence is provided of an association between a high intake of vitamin E and a lower risk of coronary heart disease in men, and public policy recommendations with regard to the use ofitamin E supplements should await the results of additional studies.
Proceedings of the National Academy of SciencesA series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.
1,896 Citations1990Jason D. Morrow, Kristina E. Hill +4 more
It is found that a series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase mechanism involving free radical-catalyzed peroxidation of arachidonic acid, and that these prostanoids may participate as pathophysiological mediators in oxidant injury.
Proceedings of the National Academy of SciencesAscorbate is an outstanding antioxidant in human blood plasma.
1,875 Citations1989Balz Frei, Laura England +1 more
The data demonstrate that ascorbate is the most effective aqueous-phase antioxidant in human blood plasma and suggest that in humans ascorBate is a physiological antioxidant of major importance for protection against diseases and degenerative processes caused by oxidant stress.
Environmental Health PerspectivesFree-radical chemistry of cigarette smoke and its toxicological implications.
1,387 Citations1985D. F. CHURCH, W. A. PRYOR
Cigarette smoke contains two very different populations of free radicals; it is suggested that this Q/QH2 polymer is an active redox system that is capable of reducing molecular oxygen to produce superoxide, eventually leading to hydrogen peroxide and hydroxyl radicals.
Trends in Biochemical SciencesThe measurement and mechanism of lipid peroxidation in biological systems
1,268 Citations1990John M.C. Gutteridge, Barry Halliwell
Currently available assays for measuring peroxidation are reviewed--the more specific the assay used, the less peroxide is found in healthy human tissues and body fluids.
Proceedings of the National Academy of SciencesNon-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids.
736 Citations1992Jason D. Morrow, Joseph Awad +3 more
The formation of these phospholipid species in lipid bilayers may contribute in an important way to alterations in fluidity and integrity of cellular membranes, well-known sequelae of oxidant injury.
Journal of Epidemiology & Community HealthCigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers.
702 Citations1978Richard Doll, Richard Peto
In a 20-year prospective study on British doctors, smoking habits were ascertained by questionnaire and lung cancer incidence was monitored, there was certainly some statistically significant upward curvature of the dose-response relationship in the range 0-40 cigarettes/day, which may help explain why bronchial carcinomas chiefly arise in the upper bronchi.
Biochemical JournalGas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid
471 Citations1991Balz Frei, Trudy M. Forte +2 more
The results support the concept of an increased vitamin C utilization in smokers, and suggest that lipid peroxidation induced by oxidants present in the gas phase of CS leads to potentially atherogenic changes in lipoproteins.
American Journal of Public HealthThe influence of smoking on vitamin C status in adults.
340 Citations1989Gordon Schectman, James C. Byrd +1 more
The data suggest that even though smoking adversely affects preferences for vitamin C rich foods, the inverse association between smoking and serum vitamin C levels occurs independently of dietary intake.
Journal of Clinical InvestigationFormation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation.
319 Citations1992Jason D. Morrow, Joseph Awad +5 more
These studies examine the in vivo formation of a unique series of PGF2-like compounds (F2-isoprostanes) derived from free radical-catalyzed nonenzymatic peroxidation of arachidonic acid to understand further the formation of these compounds in vivo.
American Heart JournalUpdate on the role of cigarette smoking in coronary artery disease
312 Citations1981William B. Kannel
PubMedSimultaneous determination of retinol, tocopherols, carotenes and lycopene in plasma by means of high-performance liquid chromatography on reversed phase.
283 Citations1991D Hess, H Keller +3 more
A method for laboratory routine is reported to separate simultaneously retinol, tocopherols, alpha- andbeta-carotene, lycopene and beta-cryptoxanthin in human plasma or serum by HPLC on reversed phase starting from one extract.
Journal of Clinical InvestigationFormation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro.
238 Citations1994Shaina M. Lynch, Jason D. Morrow +2 more
The data suggest that F2-isoprostanes are useful markers of LDL oxidation in vivo, and their formation in LDL demonstrated here may also have important implications for the etiology of cardiovascular disease.
Methods in enzymology on CD-ROM/Methods in enzymology[16] Mass spectrometry of prostanoids: F2-isoprostanes produced by non-cyclooxygenase free radical-catalyzed mechanism
225 Citations1994Jason D. Morrow, L.Jackson Roberts
This chapter describes the discovery of a series of prostaglandin F2-like compounds, termed “F2-isoprostanes,” that are produced in vivo in humans by a non-cyclooxygenase free radical-catalyzed mechanism involving the peroxidation of arachidonic acid.
Environmental Health PerspectivesFree-Radical Chemistry of Cigarette Smoke and Its Toxicological Implications
219 Citations1985Daniel F. Church, William A. Pryor
Journal of the American College of NutritionLower levels of vitamin C and carotenes in plasma of cigarette smokers.
201 Citations1986Ching K. Chow, Richard R. Thacker +5 more
The data suggest that chronic cigarette smoking is associated with depressed levels of plasma vitamin C and carotenes; however, the relationship between smoking and these plasma micronutrients is still unclear.
PubMedIncreased production of oxygen free radicals in cigarette smokers.
197 Citations1991J. Kalra, Archana Chaudhary +1 more
The results suggest that the increased generation of oxygen free radicals by PMN leucocytes might be responsible for an enhanced risk of various diseases related to cigarette smoking.
AtherosclerosisCigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages
190 Citations1989Dror Harats, M. Ben-Naim +4 more
The present results indicate that cigarette smoking renders plasma LDL more susceptible to subsequent peroxidative modification by cellular elements.
Free Radical Biology and MedicineRadical formation during the peroxidase catalyzed metabolism of carcinogens and xenobiotics: The reactivity of these radicals with GSH, DNA, and unsaturated lipid
165 Citations1988Peter J. O’Brien
Radicals generated by the peroxidase catalyzed oxidation of a wide variety of substrates oxidize GSH, NADH, or arachidonate with accompanying oxygen activation and it is still not clear whether the associated GSH oxidation, DNA strand breakage and cytotoxicity is the result of direct action by radicals.
American Journal of Clinical NutritionEffects of smoking and vitamin E on blood antioxidant status
163 Citations1991GG Duthie, JR Arthur +1 more
Smokers seem to be under a sustained oxidant stress with increased plasma-conjugated dienes and dehydroascorbate concentrations and decreased ascorbate concentrations, which are consistent with an acute-stress response.
Journal of Biological ChemistryIdentification of non-cyclooxygenase-derived prostanoid (F2-isoprostane) metabolites in human urine and plasma.
159 Citations1993Joseph Awad, Jason D. Morrow +2 more
Quantification of these isoprostane metabolites in urine and plasma may provide a reliable index of endogenous isOProstane production which could prove to be an important advance in the authors' ability to assess oxidant stress in vivo in humans.
Proceedings of the National Academy of SciencesCholesteryl ester accumulation in macrophages incubated with low density lipoprotein pretreated with cigarette smoke extract.
145 Citations1988Masataka Yokode, Tomoyuki Kita +4 more
It is suggested that CS extract alters low density lipoprotein into a form recognized and incorporated by macrophages, which could explain the increased incidence of atherosclerosis and coronary heart disease in smokers.
Biochemical PharmacologyEffect of oxygen tension on the generation of F2-isoprostanes and malondialdehyde in peroxidizing rat liver microsomes
128 Citations1994Atkinson W. Longmire, Larry L. Swift +4 more
It is demonstrated that higher O2 tensions do not block formation of F2-isoprostanes and validate their usefulness for assessing lipid peroxidation under high, as well as low, oxygen tension.
Clinical Pharmacology & TherapeuticsSmoking-induced changes in nicotine disposition: Application of a new HPLC assay for nicotine and its metabolites
124 Citations1982Gabriel A. Kyerematen, Michael D Damiano +2 more
The presence of nicotine and its principal metabolites in a morning specimen of urine obtained from nonsmokers before 14C‐nicotine administration suggests ubiquitous, passive exposure to and absorption of chemicals present in cigarette smoke.
Free Radical Biology and MedicineCigarette smoke elicits leukocyte adhesion to endothelium in hamsters: Inhibition by CuZn-SOD
116 Citations1993Hans‐Anton Lehr, Eberhard Kress +5 more
In vivo results suggest a novel pathomechanism of CS-induced cardiovascular pathology in hamsters pretreated with superoxide dismutase, suggesting a key role of superoxide in this event.
Annals of the New York Academy of SciencesCigarette Smoking and Oxidative Damage in the Lunga
114 Citations1993Ching K. Chow
Metabolic adaptation, such as accumulation of vitamin E in the lung, and increased activities of superoxide dismutase in alveolar macrophages and pulmonary tissues of chronically smoked animals may enable smoked subjects to counteract oxidative stress and to resist further damage to smoke exposure.
American Journal of Clinical NutritionVitamin C Status of Cigarette Smokers an Nonsmokers
74 Citations1970Omer Pelletier
PubMedAge, sex, cigarette smoking and indices of free radical activity in healthy humans.
72 Citations1993A. Bridges, N. Scott +2 more
This study of normal subjects describes an age related increase in malondialdehyde levels, the rate of which is influenced by sex and smoking status, as in humans, plasma thiol levels decrease with increasing age, females have higher red cell glutathione and there is a significant inverse relationship between red blood cell superoxide dismutase and glutATHione levels.
Free Radical Research CommunicationsIs Pentane a Normal Constituent of Human Breath?
47 Citations1993A Cailleux, Philippe Allain
Using a specific and sensitive gas chromatography-mass spectrometry technique pentane concentrations in breath were lower than 10 pmoles/l, probably due to the coelution of pentane with isoprene, a volatile hydrocarbon present in human breath.
