Early prostaglandin E synthesis is an obligatory event in the induction of cell proliferation in mouse epidermis in vivo by the phorbol ester TPA
Biochemical and Biophysical Research CommunicationsPublished 1 February 1980
Gerhard Fürstenberger, Friedrich Marks
Citations145
SJR quartileQ2
SJR score0.75
SNIP0.56
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TL;DR
“Ti8”-induced epidermal cell proliferation could be partially inhibited by indomethacin, whereas 4-O-methyl-TPA-induced cell proliferation was insensitive to the drug.
Abstract
Following the topical application of the phorbol ester TPA to mouse skin in vivo a rapid increase of the prostaglandin E content after 10 and 60 minutes was observed. Pretreatment of mouse skin with indomethacin abolished the first PGE peak as well as the cellular proliferation induced by TPA. Both effects could not be prevented when indomethacin was applied 30 to 60 minutes after TPA treatment, suggesting that the early increase in epidermal PGE is an obligatory event in the course of the induction of epidermal cell proliferation by TPA. A small increase of epidermal PGE was also seen after treatment with the TPA-analogue “Ti8”, whereas 4-O-methyl-TPA was inactive in this respect. “Ti8”-induced epidermal cell proliferation could be partially inhibited by indomethacin, whereas 4-O-methyl-TPA-induced cell proliferation was insensitive to the drug.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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