Chronic Myelogenous Leukemia — New Concepts
New England Journal of MedicinePublished 14 May 1981
H. Phillip Koeffler, David W. Golde
Citations245
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR
A large number of patients diagnosed with chronic myelogenous leukemia with a marked prophylactic response to chemotherapy also have a history of atypical Irving's disease.
Abstract
CHRONIC myelogenous leukemia (CML) is a clonal myeloproliferative disorder arising from neoplastic transformation at the level of the pluripotent stem cell and characterized clinically by a marked overproduction of granulocytes. The disease was probably first identified in 1845 by Craigie,1 Bennett,2 and Virchow,3 who called attention to the prominent splenomegaly and "suppuration of the blood." In 1960, Nowell and Hungerford described an abnormal, small chromosome (the Philadelphia, or Ph1, chromosome) in patients with this disorder.4 Because of the typical clinical picture and the specific chromosomal abnormality, CML is perhaps the best defined of the myeloproliferative disorders. In western countries, . . .
Keywords
Medicine
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147 Citations1974Alec Morley, Judith A. Blake
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146 Citations1970A.A. Sandberg, D. K. Hossfeld
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135 Citations1976LoAnn Peterson, Clara D. Bloomfield +1 more
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128 Citations1977Susan N. Rosenthal, Canellos Gp +2 more
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CancerHydroxyurea therapy in chronic myelogenous leukemia
120 Citations1972B. J. Kennedy
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120 Citations1975A Morley, K Trainor +1 more
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110 Citations1979Tucker W. LeBien, John Hozier +2 more
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107 Citations1978J Breton-Gorius, F Reyes +3 more
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105 Citations1952William N. Valentine, William S. Beck +3 more
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99 Citations1978George Janossy, RK Woodruff +9 more
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98 Citations1974Janet D. Rowley
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98 Citations1973Malcolm A.S. Moore, Donald Metcalf
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97 Citations1961Arthur Haut, W. S. Abbott +2 more
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95 Citations1972H. Vodopick, Elizabeth M. Rupp +3 more
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95 Citations1978Francis Wiener, Jack Spira +3 more
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PubMedMultiparameter studies in lymphoid leukemias.
95 Citations1979Daniel Catovsky, Sally M. Pittman +9 more
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94 Citations1976M. E. J. Beard, Jill Durrant +9 more
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94 Citations1972Athanasios Theologides
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93 Citations1974John M. Goldman, K. H. Th'ng +1 more
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91 Citations1975A. S. D. Spiers, A.G. Baikie +7 more
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91 Citations1979John M. Goldman, Daniel Catovsky +3 more
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89 Citations1958W. J. Mitus, L. J. Bergna +2 more
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88 Citations1978Francis Wiener, Shinsuke Ohno +3 more
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86 Citations1976Joseph E. Sokal
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Scandinavian Journal of HaematologyCytogenetic Evidence for Splenic Origin of Blastic Transformation in Chronic Myeloid Leukaemia
85 Citations1974Felix Mitelman, L. Brandt +1 more
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New England Journal of MedicineLeukopoietic Activity in Human Urine
84 Citations1970William A. Robinson, Beverley L. Pike
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82 Citations1972GeorgeP. Canellos, Jacqueline Whang‐Peng
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82 Citations1974D Metcalf, Michelle Moore +2 more
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Journal of Clinical PathologyMegakaryoblastic transformation of chronic granulocytic leukaemia. An electron microscopy and cytochemial study.
81 Citations1977BJ Bain, Daniel Catovsky +3 more
The entire leukaemic cell population was found to consist and of megakaryoblasts and megAKaryocytes.
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80 Citations1977EN Forman, T Padre-Mendoza +3 more
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77 Citations1980M Coleman, RT Silver +6 more
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77 Citations1973Ronald D. Barr, Philip J. Fialkow
An indirect approach to elucidating causative factors involves determining the number of cells from which chronic myelocytic leukemia arises, and single-cell (clonal) origin would be .
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74 Citations1978Clara D. Bloomfield, Leanna L. Lindquist +3 more
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73 Citations1972R. Finney, G. A. McDonald +2 more
Following busulphan‐induced bone marrow insufficiency a patient with chronic granulocytic leukaemia has had a remission lasting 10 yr, during which time repeated chromosome studies on bone marrow have shown the persistence of a majority of Ph1 negative cells.
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71 Citations1977RV Smalley, Jeffrey E. Vogel +2 more
A prospective chemotherapeutic attempt to convert a Ph1-positive marrow without splenectomy has induced a conversion in two of ten patients, and other regimens which might induce less nausea and vomiting and a higher rate of conversions should be sought in future attempts to alter the invariably fatal outcome of CGL.
British Journal of HaematologyChromosomes in Ph<sup>1</sup>‐Positive Chronic Granulocytic Leukaemia
69 Citations1978FIRST INTERNATIONAL WORKSHOP ON CHROMOSOMES IN LEUKAEMIA
The results of the analysis of chromosomes in CGL are presented; the results of a similar analysis in ANLL are presented in the subsequent paper.
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69 Citations1969Bruce A. Chabner, Charles M. Haskell +1 more
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69 Citations1977Susan N. Rosenthal, George P. Canellos +1 more
The erythroblastic transformation seems to represent a morphologic variant of chronic granulocytic leukemia blast crisis, without apparent prognostic or therapeutic implications.
British Journal of HaematologyMyelofibrosis in Chronic Granulocytic Leukaemia
68 Citations1979V. Clough, C. G. Geary +3 more
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68 Citations1979L B Vogler, W M Crist +4 more
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67 Citations1977Hal E. Broxmeyer, Naomi Mendelsohn +1 more
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65 Citations1978BR Greenberg, FD Wilson +2 more
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64 Citations1977A. S. D. Spiers
BloodThe Philadelphia chromosome in human macrophages
64 Citations1977DW Golde, C Burgaleta +2 more
It is concluded that the mononuclear phagocyte cell line contains the abnormal chromosome in Ph1-positive chronic myelocytic leukemia.
NatureChromosome Pattern of Bone Marrow Fibroblasts in Patients with Chronic Granulocytic Leukaemia
64 Citations1969Alice Maniatis, Sheldon Amsel +2 more
The question has arisen of the presence of a Ph1 chromosome in marrow fibroblasts in patients with chronic granulocytic leukaemia.
Acta HaematologicaThe Treatment of Terminal Metamorphosis of Chronic Granulocytic Leukaemia with Corticosteroids and Vincristine
63 Citations2009A Marmont, E Damasio
A combination of corticosteroids and vincristine achieved complete remission in 9 out of 15 cases of ‘agranular' blastic crisis supervening in chronic granulocytic leukaemia, but failed to do so in other 9 cases in which the metamorphosis was of more progressive character and with a ‘granular’ cytomorphology.
BloodChemotherapy of the blastic phase of chronic granulocytic leukemia: hypodiploidy and response to therapy
62 Citations1976Canellos Gp, V T DeVita +4 more
Thirty-two patients in the blastic phase of Philadelphia chromosome-positive chronic granulocytic leukemia were studied in a prospective randomized trial in which vincristine--prednisone was compared with cytosine arabinoside--6-thioguanine, and seven remissions were achieved.
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