Triple helix formation by oligonucleotides on DNA extended to the physiological pH range
Journal of the American Chemical SocietyPublished 1 April 1989
Thomas J. Povsic, Peter B. Dervan
Citations246
SJR quartileQ1
SJR score5.55
SNIP2.61
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TL;DR
It is reported that oligodeoxyribonucleotides which contain 5-bromouracil and 5-methylcytosine bind duplex DNA at the same homopurine target sequence as their T/C analogues but with greater affinities and over an extended pH range.
Abstract
We report here that oligodeoxyribonucleotides which contain 5-bromouracil (Br^5U) and 5-methylcytosine (m^5C) bind duplex DNA at the same homopurine target sequence as their T/C analogues but with greater affinities and over an extended pH range. Oligonucleotides containing uracil (U) bind with lower affinity (Figure 1).
Keywords
Biochemistry, Genetics and Molecular Biology