Low density lipoproteins in atherosclerosis.
Journal of Lipid ResearchPublished 1 July 1988Open access
L L Rudel, John S. Parks, F L Johnson, John Babiak
Citations144
SJR quartileQ1
SJR score1.66
SNIP1.20
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
It seems clear that the low density lipoproteins are important in initiation and exacerbation of coronary artery atherosclerosis in the experimental primate model as well as in man.
Abstract
Compositional heterogeneity of LDL A. Metabolic origin B. Consequences in arterial wall A. VLDL conversion to LDL B. VLDL-independent LDL formation 111.LDL formation IV. LDL catabolism
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Annual Review of BiochemistryThe Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
2,464 Citations1977L J Goldstein, S. M. Brown
The LDL Pathway is a Vehicle for Normal Human PhySIOLOGY and the PATHOGENESIS of ATHEROSCLEROSIS and its implications for normal human physiology and the pathogenesis of AtherOSCLerosis are discussed.
CellThe human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA
1,406 Citations1984Tokuo Yamamoto, Christopher G. Davis +5 more
Transfection of simian COS cells with the human LDL receptor cDNA linked to the SV40 early promoter resulted in expression of functional cell surface receptors.
Journal of Lipid ResearchIdentification of multiple subclasses of plasma low density lipoproteins in normal humans.
995 Citations1982R.M. Krauss, David J. Burke
Use of a lipid-staining procedure allowed identification of electrophoretic bands in whole plasma which corresponded to those seen in isolated LDL, eliminating the possibility that ultracentrifugation was responsible for formation of the subspecies detected by the gradient gel procedure.
ScienceRegulation of Plasma Cholesterol by Lipoprotein Receptors
952 Citations1981Michael S. Brown, Petri T. Kovanen +1 more
The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man.
ScienceThe Role of Lipids and Lipoproteins in Atherosclerosis
928 Citations1950John W. Gofman, Frank T. Lindgren +6 more
This work states that coronary artery ocelusions in young men from 20 to 40 years of age testifies to the fallacy of the idea that atheroselerosis is a problem of the aged or senile, and there is still no agreement on the sequence of pathogenetic events, etiol- ogy, or treatment of atheroselserosis.
Biochemical and Biophysical Research CommunicationsA protein cofactor of lecithin:Cholesterol acyltransferase
723 Citations1972C J Fielding, Virgie G. Shore +1 more
One of the major proteins present gave a maximal rate of esterification similar to that found with the native lipoprotein, while the other major lipop protein was inactive as a cofactor but significantly reduced activity produced by the cofactor protein.
Proceedings of the National Academy of SciencesAssociation of coronary atherosclerosis with hyperapobetalipoproteinemia [increased protein but normal cholesterol levels in human plasma low density (beta) lipoproteins].
637 Citations1980Allan D. Sniderman, Stan Shapiro +4 more
Results indicate that not only does LDL B better separate coronary and noncoronary groups than other lipid parameters studied, but also, among those with coronary artery disease, there exists a group with normal LDL cholesterol but with levels of LDL B protein similar to those observed in type II hyperlipoproteinemia.
Journal of Clinical InvestigationThe metabolism of low density lipoprotein in familial type II hyperlipoproteinemia
631 Citations1972Terry Langer, Warren Strober +1 more
The pathologic elevation of plasma LDL concentration in the individuals with type II hyperlipoproteinemia studied here is due to a decreased fractional rate of LDL degradation rather than to an abnormality of LDL synthesis, which may be secondary to an underlying abnormality in lipid metabolism.
Journal of Clinical InvestigationLipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.
541 Citations1983M S Brown, J L Goldstein
The chylomicron remnant/remnant receptor system is to exogenous cholesterol transport as the LDL/LDL receptor system was to endogenous cholesterol transport, and can be considered the primary transport mechanism for endogenous cholesterol.
Advances in lipid researchThe Metabolic Role of Lecithin: Cholesterol Acyltransferase: Perspectives from Pathology
475 Citations1973John A. Glomset, Kaare R. Norum
This chapter discusses the metabolic role of enzyme lecithin called cholesterol acyltransferase (LCAT), which is to transport unesterified cholesterol synthesized in peripheral tissues to the liver.
New England Journal of MedicineLiver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia
445 Citations1984David W. Bilheimer, Joseph L. Goldstein +3 more
It is concluded that a genetically determined deficiency of LDL receptors can be largely reversed by liver transplantation, underscoring the importance of hepatic LDL receptors in controlling the plasma level of LDL cholesterol in human beings.
Proceedings of the National Academy of SciencesRegulatory role for hepatic low density lipoprotein receptors in vivo in the dog.
425 Citations1981Petri T. Kovanen, D W Bilheimer +3 more
CirculationBlood Lipids and Human Atherosclerosis
417 Citations1950John W. Gofman, Hardin B. Jones +4 more
With this technic it is possible to demonstrate the presence of certain lipid and lipoprotein components which are related to coronary atherosclerosis, to hypertension and to other diseases associated with atheros sclerosis, such as diabetes mellitus, the nephrotic syndrome and hypothyroidism.
Journal of Clinical InvestigationTwo independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors.
376 Citations1981Robert W. Mahley, David Y. Hui +2 more
The importance of the E apoprotein and the apo-E receptors in mediating lipoprotein clearance, including chylomicron remnants, by the liver of adult dogs, swine, and man is suggested.
Journal of Biological ChemistryDeterminants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat.
364 Citations1980E. Windler, Y S Chao +1 more
The results are consistent with the hypothesis that one or more of the C apolipoproteins opposes and apoledipoprotein E promotes recognition of triglyceride-rich lipoproteins by a hepatic receptor.
Biochemical JournalCharacterization of plasma lipoproteins separated and purified by agarose-column chromatography
323 Citations1974Lawrence L. Rudel, Jason A. Lee +2 more
The agarose-column separation technique offers the advantage of a two- to three-fold saving in time and the column-elution pattern serves as a recording of the size distribution of lipoproteins in plasma.
Proceedings of the National Academy of SciencesDietary saturated triacylglycerols suppress hepatic low density lipoprotein receptor activity in the hamster.
316 Citations1985D K Spady, J M Dietschy
Findings indicated that receptor-mediated LDL transport was suppressed approximately equal to 30% by cholesterol feeding alone and this was unaffected by the addition of polyunsaturated triacylglycerols to the diet.
Proceedings of the National Academy of SciencesSaturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits.
315 Citations1981Petri T. Kovanen, M S Brown +3 more
It is suggested that, as a result of the saturation and suppression of receptors, the hepatic removal of beta-VLDL in the cholesterol-fed rabbit fails to increase commensurate with the diet-induced increase in beta- VLDL synthesis and profound hypercholesterolemia ensues.
Journal of Lipid ResearchStudies of low density lipoprotein molecular weight in human beings with coronary artery disease.
313 Citations1985John R. Crouse, John S. Parks +2 more
D density gradient ultracentrifugation was used to characterize LDL in more detail in a subset of volunteers who had a wide range of plasma triglyceride concentrations, and LDL mean hydrated density was inversely related to LDL MW and increased as triglyceride increased.
Journal of Clinical InvestigationMetabolism of apolipoprotein B in large triglyceride-rich very low density lipoproteins of normal and hypertriglyceridemic subjects.
299 Citations1984C.J. Packard, Alison F. Munro +3 more
It is suggested that the very low density lipoprotein consists of a complex mixture of particles with different origins and fates within the Sf 20-100 flotation range, which represents remnants of larger triglyceride-rich particles which are catabolized slowly and feeds little apolipoprotein B into low densitylipoprotein.
Journal of Lipid ResearchEffect of very low-density lipoproteins on lipid transfer in incubated serum
286 Citations1965Alex V. Nichols, L. Smith
Journal of Clinical InvestigationEffects of dietary cholesterol and fatty acids on plasma lipoproteins.
262 Citations1982Gustav Schonfeld, Wolfgang Patsch +4 more
The response of LDL to dietary manipulations is consonant with epidemiologic data relating diets high in cholesterol and saturated fat to atherogenesis, and the response of HDL2 is opposite to that of its putative role as a negative risk factor.
Proceedings of the National Academy of SciencesHepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.
261 Citations1982Tomoko Kita, J L Goldstein +4 more
It is concluded that the rabbit liver normally has at least two genetically distinct lipoprotein uptake mechanisms, both of which recognize chylomicron remnants: (i) the LDL receptor and (ii) a specific chylomaticron remnant uptake mechanism that is not measured adequately by current in vitro membrane binding assays.
Journal of Lipid ResearchChanges in plasma very low density and low density lipoprotein content, composition, and size after a fatty meal in normo- and hypertriglyceridemic man.
258 Citations1979T.G. Redgrave, L. A. Carlson
Four subfractions of plasma VLDL characterized by decreasing Sf value and LDL were isolated by density gradient preparative ultracentrifugation from normotriglyceridemic and hypertriglyceridemia subjects in the fasting state and after a fatty meal to show that the hyperlipidemia of type IV subjects was accounted for by an increase in total numbers of VLDl and a shift in the distribution of V LDL towards particles of larger diameter.
Advances in lipid researchLipoprotein Metabolism1 1In preparation of this study, Dr. Eisenberg was supported in part through the Special Foreign Currency Program of the National Library of Medicine, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland, under an agreement with the Israel Journal of Medical Sciences, Jerusalem, Israel.
254 Citations1975Shlomo Eisenberg, Robert I. Levy
Proceedings of the National Academy of SciencesComposition and distribution of low density lipoprotein fractions in hyperapobetalipoproteinemia, normolipidemia, and familial hypercholesterolemia.
246 Citations1983Ba‐Bie Teng, Gilbert R. Thompson +4 more
It is confirmed that considerable heterogeneity exists between LDL subfractions within individuals but, in addition, there are also marked--and apparently characteristic--differences in LDL composition amongst normal subjects and patients with hyperapobetalipoproteinemia or familial hypercholesterolemia.
Journal of Lipid ResearchMetabolsim of apoB and apoC lipoproteins in man: kinetic studies in normal and hyperlipoproteininemic subjects
245 Citations1978M. Berman, Megan Hall +5 more
The kinetics of apolipoproteins B and C were studied in 14 normal and hyperlipoproteinemic subjects after injection of exogenously-labeled very low density lipoprotein (VLDL) particles, finding a slowdown of the stepwise delipidation process in all hyperlipemic individuals studied.
Advances in lipid researchThe Interaction of Lipids and Lipoproteins with the Intercellular Matrix of Arterial Tissue: Its Possible Role in Atherogenesis
231 Citations1982Germán Camejo
The multiple lines of evidence suggest the relevance of the intima-medial extracellular matrix to the interactions of plasma lipoproteins with the arterial wall and its' possible role in atherogenesis are presented.
Proceedings of the National Academy of SciencesDelayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.
210 Citations1982Tomoko Kita, M S Brown +2 more
In rabbits, the LDL receptor mediates the rapid removal of VLDL and IDL from plasma, and a deficiency of LDL receptors leads to an enhanced conversion of V LDL to LDL, indicating a massive increase of plasma LDL levels in homozygous WHHL rabbits.
Journal of Biological ChemistryReceptor-dependent and receptor-independent degradation of low density lipoprotein in normal rabbits and in receptor-deficient mutant rabbits.
200 Citations1982R C Pittman, T E Carew +4 more
Low density lipoprotein (LDL) catabolism was studied using WHHL rabbits, an inbred strain deficient in LDL receptor activity and, thus, an animal model for homozygous familial hypercholesterolemia, and there was no evidence that the increased degradation occurred in any special subset of "scavenger" cells.
Journal of Lipid ResearchReceptor-mediated low density lipoprotein catabolism in man.
182 Citations1979J. Shepherd, S Bicker +2 more
It is concluded that the specific LDL receptor mechanism operates in vivo and probably accounts for 33% and 16% of overall LDL catabolism in normal and heterozygous familial hypercholesterolemic subjects, respectively.
Proceedings of the National Academy of SciencesMetabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in normal and lipoprotein lipase-deficient humans.
175 Citations1984A.F.H. Stalenhoef, Mary J. Malloy +2 more
The results suggest that the reported variability of the conversion of VLDL to LDL may be related to the size and composition of the particles secreted from the liver.
Journal of Biological ChemistryReversible modification of human plasma low density lipoproteins toward triglyceride-rich precursors. A mechanism for losing excess cholesterol esters.
162 Citations1982Richard J. Deckelbaum, S Eisenberg +4 more
AtherosclerosisSimultaneous measurement of apolipoprotein B turnover in very-low- and low-density lipoproteins in familial hypercholesterolaemia
155 Citations1977Anne K. Soutar, N. B. Myant +1 more
The liver may be the source of the VLDL-independent pathway of apoB synthesis in homozygous FH, involving direct secretion into the circulation of an apOB-containing lipoprotein of density >1.006 g/ml.
Journal of Lipid ResearchThe formation of LDL: mechanisms and regulation
146 Citations1984Richard J. Havel
In this brief review, those aspects of VLDL metabolism that are central to the mechanism of LDL formation are described and recently discovered factors that influence the extent to which V LDL particles are converted to LDL are described.
AtherosclerosisInteraction of low density lipoproteins with arterial proteoglycans The role of charge and sialic acid content
139 Citations1985Germán Camejo, Aura López +2 more
The results indicate that at low ionic strength and physiological Ca2+-concentration and pH, the surface charge of LDL is an important modulator of the interaction with the arterial proteoglycan.
Journal of Clinical InvestigationStudies on the Structure of Low Density Lipoproteins Isolated from Macaca Fascicularis Fed an Atherogenic Diet
135 Citations1978Alan R. Tall, Donald Small +2 more
Diet-induced changes in the lipid composition of precursor lipoproteins of LDL appeared to lead to the existence of smectic-like cholesterol ester in LDL above body temperature, which probably account for the previously documented correlation between increased LDL molecular weight and atherosclerosis in this species.
Journal of Molecular MedicineRegulation of cholesterol metabolism in man and in other species
126 Citations1984John M. Dietschy
The liver and intestine are generally the most important organs for the synthesis of cholesterol, although recent data indicate that nearly all of the remaining tissues of the body also are capable of significant cholesterol synthesis.
Journal of Biological ChemistryCorrelation of low and high density lipoprotein binding in vivo with rates of lipoprotein degradation in the rat. A comparison of lipoproteins of rat and human origin.
118 Citations1982H. R. Koelz, Bette C. Sherrill +2 more
In the rat, the adrenal gland and liver manifested the greatest amounts of rLDL binding in vivo, but activity also was found in spleen, lung, kidney, ovary, and intestine, and little or no such binding was found utilizing either methyl-rLDL or hLDL.
Journal of Lipid ResearchPreferential enrichment of large-sized very low density lipoprotein populations with transferred cholesteryl esters.
115 Citations1985S Eisenberg
The data demonstrate that large-sized, triglyceride-rich VLDL particles are preferred acceptors for transferred cholesteryl esters, and it is suggested that enrichment of very low density lipoproteins with cholesterol esters reflects the triglyceride content of the particles.
Journal of Lipid ResearchCholestyramine-induced changes in low density lipoprotein composition and metabolism. I. Studies in the guinea pig.
104 Citations1985Joseph L. Witztum, Stephen G. Young +3 more
The studies show that the effects of bile sequestration are complex and that the compositional changes produced have profound metabolic consequences and the implications for interpretation of LDL turnover studies are discussed.
Journal of Lipid ResearchLipid transfer proteins
100 Citations1984D.B. Zilversmit
The distribution of lipid transfer proteins, how these proteins have been utilized to study lipid asymmetry in biological and in artificial membranes, and the effect of membrane lipid modification on enzyme activities are reviewed.
Familial Lipoprotein Deficiency
93 Citations1978Gerd Assmann
There are three genetically determined disorders in which one or more of the lipoprotein families are absent from plasma or their concentrations are extremely low: abetalipoproteinemia, Hypocholesterolemia, and Tangier disease.
Arteriosclerosis An Official Journal of the American Heart Association IncPresence of multiple subpopulations of lipoproteins of intermediate density in normal subjects.
87 Citations1986T A Musliner, C. Giotas +1 more
Analysis of human plasma by gradient gel electrophoresis revealed multiple distinct bands in the size range between very low density (VLDL) and low density lipoproteins (LDL), which could account for the discrete subspecies of LDL observed in human plasma.
AtherosclerosisThe interaction of low density lipoproteins with arterial proteoglycans
86 Citations1980Germán Camejo, Harry Acquatella +1 more
It is proposed that the relation between LDL-LCP reactivity and clinical manifestations of atherosclerotic heart disease warrant more stringent epidemiological studies to establish whether, besides LDL levels, LDL structural features associated with an increased affinity for arterial components may contribute to the rate of progress of the atherosclerosis lesion.
Journal of Lipid ResearchEffects of the degree of saturation of dietary fat on the hepatic production of lipoproteins in the African green monkey.
83 Citations1985F L Johnson, Richard W. St. Clair +1 more
The data show that dietary polyunsaturated fat decreased plasma LDL size even though it increased the cholesteryl ester content of lipoproteins secreted by the liver, and intravascular formation of plasma LDL from hepatic precursor lipoproteinins appears to include the removal of relatively greater amounts of cholesterolyl esters from the precursor lipiproteins in polyuns saturated fat-fed animals.
Journal of Biological ChemistryModulation of apolipoprotein B antigenic determinants in human low density lipoprotein subclasses.
81 Citations1985Bunyen Teng, Allan D. Sniderman +4 more
It is of interest that the antigenic determinants recognized by 3F5 and 4G3 are close to the LDL receptor recognition site on LDL apo-B, and it is possible that the reduced immunoreactivity of these determinants in dense LDL may be the in vitro correlate of the reduced fractional catabolics rate of dense LDL compared to buoyant LDL previously observed in vivo.
Journal of Clinical InvestigationStudies on the production of low density lipoproteins by perfused livers from nonhuman primates. Effect of dietary cholesterol.
78 Citations1983Fred L. Johnson, Richard W. St. Clair +1 more
In spite of this increase, enlarged cholesteryl ester-rich LDL were not found in the perfusate, suggesting that large molecular weight plasma LDL are not directly secreted by the liver but instead probably result from further intravascular metabolism of cholesterolipid-enriched hepatic precursor lipoproteins.
Arteriosclerosis An Official Journal of the American Heart Association IncDietary ethanol-induced modifications in hyperlipoproteinemia and atherosclerosis in nonhuman primates (Macaca nemestrina).
78 Citations1981L L Rudel, Charles W. Leathers +2 more
The high correlations found between lipoproteln characteristics and atherosclerosis severity suggest that the effect of ethanol in reducing the development of Atherosclerosis may have been mediated through Its effects on the plasma llpoprotelns.
Molecular Aspects of MedicineLipoprotein Lipase: Its physiological and clinical significance
76 Citations1983M. Hamosh, Paul Hamosh
Journal of Biological ChemistryThe interaction of human plasma glycoaminoglycans with plasma lipoproteins.
75 Citations1975Yoshifumi Nakashima, Nicola Di Ferrante +2 more
Results suggest that the sulfate-rich plasma GAG, consisting of two glycan chains linked to a peptide backbone, cause agglutination by binding to two or more formocells, in contrast, the less-sulfated plasma G AG, are incapable of causing agglUTination but may prevent it by covering specific binding sites present on the coated cells.
Journal of Biological ChemistryActivation of lecithin cholesterol acyltransferase by human apolipoprotein E in discoidal complexes with lipids.
72 Citations1985Nora L. Zorich, Alain M. Jonas +1 more
Differences in lecithin cholesterol acyltransferase activation by apo-A-I and api-E are primarily a result of different affinities of the enzyme for the particles but that the rate-limiting step of the reaction is comparable for both complexes.
Journal of Lipid ResearchMale–female variability in the dietary cholesterol-induced hyperlipoproteinemia of cynomolgus monkeys (Macaca fascicularis).
70 Citations1978L L Rudel, L. L. Pitts
The characteristics of dietary cholesterol-induced hyperlipoproteinemia were studied in adult Macaca fascicularis to determine if significant male--female differences could be identified and chemical composition differences were also noted.
Clinica Chimica ActaAnomalous low density lipoproteins in familial hyperbetallpoproteinaemia
69 Citations1970Joan Slack, G.L. Mills
The hypothesis that familial hyperbetalipoproteinaemia is not only associated with an increase in quantity of LDL but that an abnormal lipoprotein is present is supported.
Journal of Lipid ResearchEvaluation of a high-performance liquid chromatography method for isolation and quantitation of cholesterol and cholesteryl esters.
68 Citations1981R. M. Carroll, L L Rudel
Results obtained by this method show good agreement with chemical and gas-liquid chromatographic methods for quantitation of cholesterol and determination of cholesteryl ester percentage compositions.
Journal of Lipid ResearchIs hypertriglyceridemic very low density lipoprotein a precursor of normal low density lipoprotein?
65 Citations1985Y Oschry, Thomas Olivecrona +2 more
In vitro lipolysis studies support the conclusion that not all HTG-VLDL can be metabolized to LDL, as well as IDL and LDL, and an abnormal enrichment of cholesteryl ester-rich product that can never become LDL is suggested.
Proceedings of the National Academy of SciencesON THE CONFORMATIONAL INSTABILITY OF HUMAN SERUM LOW-DENSITY LIPOPROTEIN: EFFECT OF TEMPERATURE
62 Citations1969A M Scanu, Harvey B. Pollard +2 more
When examined by circular dichroism and ultraviolet spectroscopy, human serum low-density lipoprotein (LDL) and its delipidated product, apo LDL, exhibited reversible thermal changes to support a constraining role by lipids on the observed structural instability of the apoprotein.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid MetabolismMetabolism of lipoproteins in nonhuman primates. studies on the origin of low density lipoprotein apoprotein in the plasma of the squirrel monkey
59 Citations1975D. Roger Illingworth
The results indicate that most, but not all, of the newly synthesized apoprotein B enters plasma in very low density lipoproteins and that the low concentrations of this lipoprotein in squirrel monkey plasma are a consequence of its rapid turnover.
Journal of Clinical InvestigationUse of monoclonal anti-receptor antibodies to probe the expression of the low density lipoprotein receptor in tissues of normal and Watanabe heritable hyperlipidemic rabbits.
55 Citations1984M Huettinger, Wolfgang J. Schneider +3 more
The finding that the radioiodinated anti-LDL receptor monoclonal antibody is cleared from plasma 6-10-fold faster in normal than in WHHL rabbits raises the general possibility that the total number of cell surface receptors expressed by an animal or human in vivo can be estimated by measuring the rate of clearance of an intravenously injected monoconservative directed against the receptor of interest.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid MetabolismMEtabolism by cells in culture of low-density lipoproteins of abnormal composition from non-human primates with diet-induced hypercholesterolemia
54 Citations1980Richard W. St. Clair, Jonathan J. Mitschelen +1 more
Nearly twice as much cholesterol accumulated in cells incubated with hypercholesterolemic LDL compared with normal LDL, and this differential could not be explained by differences in metabolism of the two lipoproteins, suggesting that some cholesterol entered the cells independent of the uptake of the intact LDL molecule.
Journal of Biological ChemistryCharacterization of antigenic determinants on human solubilized apolipoprotein B. Conformational requirements for lipids.
54 Citations1984Yves L. Marcel, Mireille Hogue +2 more
Three types of antigenic determinants have been identified on apo-B: a conformational determinant which requires the presence of amphipathic lipids such as lecithin and cholesterol or SDS micelles, an example being that recognized by 2D8, and another which represents different conformations which require the association of apolipoprotein B with lipid structures having a cholesteryl ester hydrophobic core.
Journal of Lipid ResearchA species comparison of low density lipoprotein heterogeneity in nonhuman primates fed atherogenic diets.
51 Citations1988C A Marzetta, L L Rudel
The average cynomolgus monkey LDL was larger, more polydisperse, less dense, and appeared to contain more apoE than the average African green monkey LDL, and one or all of these differences might help explain the increased susceptibility to diet-induced atherosclerosis seen in cynomOLgus monkeys.
Journal of Lipid ResearchCharacterization of lipoprotein in a kindred with familial hypercholesterolemia
48 Citations1982Wolfgang Patsch, Richard E. Ostlund +3 more
The LDL of members of the kindred affected with familial hypercholesterolemia (FH) differed from LDL of unaffected members by containing more molecules of cholesteryl ester and less triglyceride, even when LDL were matched for molecular weight, suggesting that, whatever genetic or other factors limit LDL mass, these factors remain operative in FH.
Journal of Biological ChemistrySynthesis and release of low density lipoproteins by the isolated perfused pig liver.
45 Citations1977N Nakaya, B H Chung +2 more
The present studies conclude that the low density lipoproteins in the perfusate from pig liver perfusions were derived mainly from a preformed liver pool, but also partly from de novo synthesis by the liver.
American Journal of Physiology-Endocrinology and MetabolismMetabolism of apoprotein B in cynomolgus monkey: evidence for independent production of low-density lipoprotein apoprotein B
39 Citations1983Ira J. Goldberg, Ngoc‐Anh Le +3 more
A significant proportion of cynomolgus monkey low- density lipoproteins are produced either by direct hepatic secretion or by rapid conversion of lower-density lipoprotein before they appear in the peripheral circulation.
Proceedings of the National Academy of SciencesREVERSIBLE THERMAL CONFORMATION CHANGES IN HUMAN SERUM LOW-DENSITY LIPOPROTEIN
38 Citations1969Dorr G. Dearborn, D.B. Wetlaufer
Human serum beta(1) (LDL(2) lipoprotein was preparatively divided into three subfractions on the basis of density, and the protein conformation was investigated by optical rotatory dispersion and circular dichroism.
CirculationThe Circulatory Effects of Reserpine
37 Citations1955E. G. McQueen, A. E. Doyle +1 more
Evidence is presented which suggests that part at least of the hypotensive action is mediated through the sympathetic nervous system in man and in animals and there seems also to be a direct vascular action in animals.
LipidsHuman low density lipoprotein structure: Correlations with serum lipoprotein concentrations
32 Citations1983Charles A. Nelson, Manford D. Morris
Human low density lipoproteins (LDL) were isolated and purified from individuals having widely differing serum lipid concentrations and the molecular weight of LDL was inversely proportional to its density, and thus inversely proportion to its protein/lipid ratio which was confirmed by composition measurements.
BiochemistryTemperature dependence of the optical activity of human serum low density lipoprotein. Role of lipids
31 Citations1975G. Chi Chen, John P. Kane
Observations suggest that a substantial part of the thermal change in the CD spectrum of LDL between 208 and 210 nm may be attributable to lipids.
BiochemistryThermotropic properties and molecular dynamics of cholesteryl ester rich very low density lipoproteins: effect of hydrophobic core on polar surface
30 Citations1984Joel D. Morrisett, John W. Gaubatz +5 more
Results indicate that the two DSC transitions in CER-VLDL do not directly correlate with the smectic----cholesteric and cholesteric----isotropic transitions exhibited by pure cholesteryl esters.
AtherosclerosisChanges in the physical behavior of low density lipoprotein in the presence of glycosaminoglycans and high density lipoprotein
28 Citations1981Magdolna Bihari‐Varga, J. Sztatisz +1 more
Temperature dependent techniques and the disappearance of birefringence indicated that in the presence of HDL the lipids within the GAG-LDL complexes existed in a liquid phase at a temperature in the vicinity of body temperature.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid MetabolismHeterogeneity in the low density lipoproteins of cholesterol fed African green monkeys (Cercopithecus aethiops)
19 Citations1978George W. Melchior, Lawrence L. Rudel
Large and small lowdensity lipoprotein particles were metabolized differently, indicating that the low density lipoproteins from cholesterol-fed African green monkeys are heterogeneous.
Clinica Chimica ActaComposition of low density lipoprotein in children with familial hyperbetalipoproteinaemia and the effect of treatment
13 Citations1972T.F. Bagnall
Data support the hypothesis that there is a specific molecular abnormality of LDL in FH, which has been studied in eight prepubertal children suffering from familial hyperbetalipoproteinaemia.
LipidsEffect of diet on fatty acids in the lipoprotein cholesteryl esters of type IIa and normal individuals
5 Citations1975Roger S. Newton, Robert E. Pitas +1 more
Four normal and two individuals with type IIa hyperlipoproteinemia were placed on the National Heart and Lung Institute Type IIa Diet for 1 week and on a normal diet the following week and the cholesterol contents of plasma and of very low density, low density and high density lipoproteins determined.
…