Membrane protein structure prediction
Journal of Molecular BiologyPublished 1 May 1992
Gunnar von Heijne
Citations1,669
SJR quartileQ1
SJR score2.21
SNIP1.13
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TL;DR
A straightforward implementation with no attempts at optimization predicts the correct topology for 23 out of 24 inner membrane proteins with experimentally determined topologies, and correctly identifies 135 transmembrane segments with only one overprediction.
Abstract
A new strategy for predicting the topology of bacterial inner membrane proteins is proposed on the basis of hydrophobicity analysis, automatic generation of a set of possible topologies and ranking of these according to the positive-inside rule. A straightforward implementation with no attempts at optimization predicts the correct topology for 23 out of 24 inner membrane proteins with experimentally determined topologies, and correctly identifies 135 transmembrane segments with only one overprediction.
Keywords
Biochemistry, Genetics and Molecular Biology
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