Attenuation of drug-induced bait shyness to a palatable solution as an increasing function of its availability prior to conditioning
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TL;DR
As revealed by extended extinction tests, the strength of resultant saccharin aversions was inversely related to preconditioner familiarity, and 20 days of flavor preexposure completely blocked aversion formation, while intermediate preexposures resulted in orderly and graded degrees of aversion attenuation.
Abstract
Different groups of rats were familiarized with a saccharin solution for 1, 3, 10, or 20 days prior to conditioning. Saccharin ingestion was then followed by intraperitoneal cyclophosphamide injection. Control Ss consumed saccharin as a novel flavor and were similarly injected with either cyclophosphamide or isotonic saline. As revealed by extended extinction tests, the strength of resultant saccharin aversions was inversely related to preconditioning saccharin familiarity. One day of saccharin preexposure failed to influence initial aversion magnitude, but resulted in an increased rate of extinction. Contrastingly, 20 days of flavor preexposure completely blocked aversion formation, while intermediate preexposures resulted in orderly and graded degrees of aversion attenuation.