Prognostic factor studies in oncology: osteosarcoma as a clinical example
International Journal of Radiation Oncology*Biology*PhysicsPublished 1 February 2001
Søren M. Bentzen
Citations31
SJR quartileQ1
SJR score2.06
SNIP1.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
An effort is needed to improve the design, conduct, and reporting of prognostic studies in oncology, as most published studies are too small to provide useful information on prognostic factors in osteosarcoma.
Abstract
An effort is needed to improve the design, conduct, and reporting of prognostic studies in oncology.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
British Journal of CancerStatistical aspects of prognostic factor studies in oncology
593 Citations1994Richard Simon, DG Altman
Some of the statistical problems common to prognostic factor studies are considered as a step towards the development of broadly acceptable principles that might guide their conduct and reporting.
CancerBone cancers
488 Citations1995Howard D. Dorfman, Bogdan Czerniak
Frequency distribution data for primary bone sarcomas have long been used to provide clues to the diagnosis of bone cancers after their identification in radiographs, and age and skeletal site are often helpful in narrowing down the probable histologic categories of bone neoplasms before biopsy.
BiometrikaThe asymptotic properties of nonparametric tests for comparing survival distributions
471 Citations1981David Schoenfeld
Radiotherapy and OncologyTowards evidence based radiation oncology: improving the design, analysis, and reporting of clinical outcome studies in radiotherapy
148 Citations1998Søren M. Bentzen
The conclusion is that the quality of RCTs need to improve in terms of their design, conduct, analysis and reporting, and a new set of guidelines for reports on treatment outcome in Radiotherapy and Oncology are presented.
BMJBone Sarcoma: Treatment by Irradiation, Amputation, or a Combination of the Two
81 Citations1971Rodney Sweetnam, J. Knowelden +1 more
A combination of the two treatments—radiotherapy followed by amputation—produced better results, in terms of survival, than amputation alone; however, the comparatively small numbers involved and the inadequacy of information about the factors dictating the choice of treatment make firm conclusions impossible.
Statistics in MedicineSurvival analysis 1982–1991: The second decade of the proportional hazards regression model
80 Citations1991Per Kraghersen Andersen
How the model is used and presented in medical journals and how improvement may be achieved are discussed and some extensions of the model are outlined.
CancerPrognostic factors in osteosarcomas. A regression analysis
80 Citations1988Søren M. Bentzen, Hans Skovgaard Poulsen +6 more
A multivariate regression analysis of survival data was performed on the retrospective material of 184 osteosarcoma patients treated at the Aarhus and Copenhagen oncology centers, Denmark, from 1963 to 1984, finding that children, adolescents, and adults ages 5 to 25 years had significantly poorer prognosis than young adults 25 to 30 years of age.
British Journal of CancerSample size: how many patients are necessary?
70 Citations1995Peter Fayers, David Machin
International Journal of Radiation Oncology*Biology*PhysicsPrognostic factors in osteosarcoma
61 Citations1980David C. Dahlin
Significant variation in likelihood of survival is probably introduced by the different manners of treatment of the primary neoplasms.
International Journal of Radiation Oncology*Biology*PhysicsCan historical controls be used in current clinical trials in osteosarcoma? Metastases and survival in a historical and a concurrent group
16 Citations1980Lars‐Åke Broström, Tomas Aparisi +5 more
The results of the study cast doubt on the suitability of historical controls in current clinical trials conducted to ascertain the effectiveness of adjuvant therapy for osteosarcoma.