Identification of an Inhibitor of Neovascularization from Cartilage
SciencePublished 15 June 1990
Marsha A. Moses, Judith Sudhalter, Róbert Langer
Citations477
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
A protein derived from cartilage was purified that inhibits angiogenesis in vivo and capillary endothelial cell proliferation and migration in vitro in three separate bioassays, and may help elucidate the mechanisms by which neovascularization is controlled in both normal and pathological states.
Abstract
Certain tissues such as cartilage are resistant to vascular invasion, yet no single tissue-derived molecule that can inhibit angiogenesis has been reported. A protein derived from cartilage was purified that inhibits angiogenesis in vivo and capillary endothelial cell proliferation and migration in vitro in three separate bioassays. This protein is also an inhibitor of mammalian collagenase. These findings may help elucidate the mechanisms by which neovascularization is controlled in both normal and pathological states.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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