The effects of handling on antibody production, mitogen responses, spleen cell number, and lymphocyte subpopulations
Life SciencesPublished 1 January 1990Open access
Jan A. Moynihan, Gary J. Brenner, David Koota, Stephen M. Breneman, Nicholas Cohen, Robert Ader
Citations36
SJR quartileQ1
SJR score1.31
SNIP1.07
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TL;DR
The effects of a simple psychosocial manipulation, handling, on immune function in BALB/c.ByJ mice were studied and demonstrate that simply picking up an animal results in modulation of the immune response.
Abstract
The effects of a simple psychosocial manipulation, handling, on immune function in BALB/c.ByJ mice were studied. Handling for two minutes/day prior to immunization was shown to be associated with a decreased primary IgG antibody response to the protein antigen keyhole limpet hemocyanin. Handling was also associated with decreased T cell proliferative responses to Concanavalin A. No reliable changes in spleen cell number or lymphocyte subsets were found. These findings demonstrate that simply picking up an animal results in modulation of the immune response. These data are also of interest for their obvious methodological implications.
Keywords
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