Hypertension and Associated Metabolic Abnormalities — The Role of Insulin Resistance and the Sympathoadrenal System
New England Journal of MedicinePublished 8 February 1996
Gerald M. Reaven, Hans Lithell, Lewis Landsberg
Citations1,446
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR
It is hypothesized that the metabolic abnormalities linked to the hypertension by a pathophysiologic process that involves the sympathoadrenal system and exerts influence on blood pressure and complications in many patients.
Abstract
Abnormalities of glucose, insulin, and lipoprotein metabolism are common in patients with hypertension. These changes can also be discerned in normotensive first-degree relatives of hypertensive patients. They are not present in patients with secondary forms of hypertension, do not necessarily improve when blood pressure is lowered pharmacologically, and may even be made worse by some forms of antihypertensive treatment. These metabolic abnormalities may play a part in both the pathogenesis and the complications of hypertension in many patients. We hypothesize that the metabolic abnormalities are linked to the hypertension by a pathophysiologic process that involves the sympathoadrenal system and exerts . . .
Keywords
Medicine
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