Cerebrospinal fluid selenium and chromium levels in patients with Parkinson's disease
Journal of Neural TransmissionPublished 16 December 1998
M. V. Aguilar, Félix Javier Jiménez‐Jiménez, J. A. Molina, I. Meseguer, C. J. Mateos-Vega, María José González‐Muñoz
Citations51
SJR quartileQ1
SJR score1.11
SNIP1.13
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The normality of CSF and serum chromium levels suggest that these values are not related with the risk for Parkinson's disease and it is possible that increased CSF selenium levels could indicate an attempt of protection against oxidative stress.
Abstract
We compared CSF and serum levels of selenium and chromium, measured by atomic absorption spectrophotometry, in 28 patients with Parkinson's disease (PD) and 43 matched controls. The CSF and serum levels of these trace metals did not differ significantly between PD patients and controls. CSF selenium and chromium levels were not correlated with age, age at onset, duration of the disease, scores of the Unified Parkinson Disease Rating Scale of the Hoehn and Yahr staging in the PD group. Although antiparkinsonian therapy did not influence significantly the CSF levels of selenium, PD patients not treated with levodopa had significantly higher CSF selenium levels than controls (p < 0.01). It is possible that increased CSF selenium levels could indicate an attempt of protection against oxidative stress. The normality of CSF and serum chromium levels suggest that these values are not related with the risk for PD.
Keywords
MedicineEnvironmental Science
NeurologyParkinsonism
11,830 Citations1967Margaret M. Hoehn, Melvin D. Yahr
Controversy over the effectiveness of therapeutic measures for parkinsonism is due partially to this wide variability and to the paucity of clinical information about the natural history of the syndrome.
Journal of NeurochemistryTransition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains
1,387 Citations1989Peter Riederer, E. Sofić +5 more
Reduced glutathione and the shift of the iron (II)/iron (III) ratio in favor of iron ( III) suggest that these changes might contribute to pathophysiological processes underlying PD.
NeurologyWhat features improve the accuracy of clinical diagnosis in Parkinson's disease
1,293 Citations1992Andrew Hughes, Yoav Ben‐Shlomo +2 more
Assessment of clinical features of 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease suggests that studies based on consultant diagnosis of PD, using standard diagnostic criteria, will include cases other than PD, thus distorting results from clinical trials and epidemiologic studies.
Annals of NeurologyThe oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
924 Citations1992S Fahn, Gerald Cohen
The evidence favoring the oxidant stress hypothesis is persuasive, but not yet fully established, and believes that this is the best hypothesis available at present.
Neuroscience LettersParkinson's disease: A disorder due to nigral glutathione deficiency?
754 Citations1982Thomas L. Perry, David V. Godin +1 more
The hypothesis that loss of nigrostriatal dopaminergic neurons results from a regional GSH deficiency could have important therapeutic implications for the management and prevention of Parkinson's disease.
NeuroscienceGlutathione peroxidase, glial cells and Parkinson's disease
457 Citations1993Philippe Damier, Étienne C. Hirsch +3 more
The data suggest that in control brains, a low density of glutathione peroxidase-positive cells surround the dopaminergic neurons the most vulnerable to Parkinson's disease, and that in parkinsonian brains, the increased number ofglutathioneperoxidases protein-containing cells may contribute to protect neurons against pathological death.
Archives of NeurologyBrain Peroxidase and Catalase in Parkinson Disease
402 Citations1975L. M. Ambani, Melvin H. Van Woert +1 more
Peroxidase and catalase activities were determined in various regions of parkinsonian brains and control brains from patients with nonneurological diseases, and these enzyme changes may be causally related to the degeneration and depigmentation of the substantia nigra neurons in Parkinson disease.
Neuroscience LettersGlutathione peroxidase activity in Parkinson's disease brain
302 Citations1985Stephen J. Kish, Caryl L. H. Morito +1 more
In the Parkinson's disease patients glutathione peroxidase activity was slightly but significantly reduced in several brain areas including substantia nigra, suggesting that this enzyme may represent one of the contributing factors leading to nigral dopamine neurone loss.
The Science of The Total EnvironmentEssentiality of chromium in humans
229 Citations1989Richard A. Anderson
Well controlled studies involving human subjects have demonstrated beneficial effects of supplemental chromium on fasting glucose, glucose tolerance, blood lipids, insulin binding, and hypoglycemic blood glucose values and symptoms.
Neuroscience LettersIncreased erythrocyte susceptibility to lipid peroxidation in human Parkinson's disease
57 Citations1988Ahmet Kılınç, A. Süha Yalçın +3 more
Both plasma lipid peroxide levels and erythrocyte susceptibility to lipid peroxidation were significantly increased in Parkinson's disease and the results suggest that ery Throcyte membrane integrity may be impaired in Parkinson't disease.
Molecular and Cellular BiochemistrySerum antioxidant enzyme activity in Parkinson's disease
52 Citations1992Jawahar Kalra, Ali H. Rajput +2 more
The activities of SOD and GSHPx in patients with PD were higher than those in normal healthy individuals, suggesting that the increased activities of these enzymes could be due to oxidative stress in the initial stages of this disease.
Annals of the Rheumatic DiseasesGlutathione redox cycle enzymes and selenium in severe rheumatoid arthritis: lack of antioxidative response to selenium supplementation in polymorphonuclear leucocytes.
48 Citations1992Ulrik Tarp, K. Stengaard‐Pedersen +2 more
The reduced antioxidant activity of the glutathione redox cycle in patients with severe RA was mainly due to the low availability of selenium, which was further supported by the response to Selenium supplementation in serum and red blood cells.
Industrial HealthSynergism of ascorbic acid and glutathione in the reduction of hexavalent chromium in vitro.
45 Citations1990Yasutomo SUZUKI
Although AsA possesses higher reducing ability than GSH, their coexistence is of importance for the reduction of chromium(VI) in biological systems because of their synergism.
Journal of Neurology Neurosurgery & PsychiatryGlutathione peroxidase in early and advanced Parkinson's disease.
40 Citations1991Peter Johannsen, G Velander +3 more
Erythrocyte glutathione peroxidase was determined as a measure of antioxidant activity and significantly lower values were found in group B than in group A, while regression analyses in groups A and B showed significant correlation between glutathion per oxidase and duration of disease, but not between age of patients.
Journal of the Neurological SciencesDistribution of arsenic, manganese, and selenium in the human brain in chronic renal insufficiency, Parkinson's disease, and amyotrophic lateral sclerosis
36 Citations1981N. Agersnap Larsen, H. Pakkenberg +3 more
Neuroscience LettersErythrocyte antioxidant activity in human patients with Parkinson's disease
34 Citations1987Judes Poirier, André Barbeau
None of the above-mentioned parameters were found altered in erythrocytes of parkinsonians, suggesting that no genetic or generalized biochemical abnormalities underly the deficiencies detected in substantia nigra.
Human & Experimental ToxicologyPoisoning with a Traditional Remedy Containing Potassium Dichromate
24 Citations1991C Michie, M D Hayhurst +3 more
A retrospective review of serum and organ levels of chromium demonstrates that charcoal haemoperfusion, peritoneal and haemodialysis are ineffective therapies for the toxin.
Biological Trace Element ResearchSelenium content and distribution in rat tissues irradiated with gamma rays
23 Citations1992I Djujić, Olga Jozanov‐Stankov +3 more
It seems that the animal tissue susceptibility to oxidative damage may be correlated to their ability to retain Se in tissues and Supplementation with selenous yeast reduces changes in Se content and distribution after irradiation.
European Journal of NeurologyDecreased serum selenium concentrations in patients with Parkinson's disease
19 Citations1995Félix Javier Jiménez‐Jiménez, J. A. Molina +8 more
Serum selenium levels were significantly lower in PD patients than in controls, and they did not correlate with age, age at onset and duration of the PD, scores of the Unified PD Rating Scale or the Hoehn and Yahr staging in the PD group, which might suggest a possible role of low serum seenium levels in the risk for, or a consequence of the oxidative stress in PD.
PubMedConcentration of nickel and chromium in serum: influence of blood sampling technique.
18 Citations1988S Bro, Jørgensen Pj +2 more
It is shown that identical results for concentrations of nickel and chromium in serum are obtained independent of whether a steel needle or a teflon i.v. cannula is used for blood sampling, provided the first 5 ml of blood are discarded.
PubMed[Glutathione defense system in various brain structures during starvation].
4 Citations1992Kerimov Bf, Aliev Sa
A significant decrease in the content of selenium and GP activity was observed under prolonged starvation and it was assumed that glutathione and enzymes of its metabolism were involved in the regulatory system of redox processes in the nervous tissues in the primary period of starvation.