Do plasma melatonin concentrations decline with age?
The American Journal of MedicinePublished 1 November 1999
Jamie M. Zeitzer, Jessica Daniels, Jeanne F. Duffy, Elizabeth B. Klerman, Theresa L. Shanahan, Derk‐Jan Dijk
Citations239
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TL;DR
The hypothesis that reduction of plasma melatonin concentration is a general characteristic of healthy aging is not supported and it is recommended that an assessment of endogenous melatonin be carried out before such treatment is used in older patients.
Abstract
These results do not support the hypothesis that reduction of plasma melatonin concentration is a general characteristic of healthy aging. Should melatonin replacement therapy or melatonin supplementation prove to be clinically useful, we recommend that an assessment of endogenous melatonin be carried out before such treatment is used in older patients.
Keywords
MedicineNeuroscience
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