Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation
Nature GeneticsPublished 18 March 2002
Eric C. Lai
Citations1,478
SJR quartileQ1
SJR score16.59
SNIP6.64
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TL;DR
A large subset of Drosophila microRNAs is shown to be perfectly complementary to several classes of sequence motif previously demonstrated to mediate negative post-transcriptional regulation, suggesting a more general role for micro RNAs in gene regulation through the formation of RNA duplexes.
Abstract
Micro RNAs are a large family of noncoding RNAs of 21-22 nucleotides whose functions are generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly complementary to several classes of sequence motif previously demonstrated to mediate negative post-transcriptional regulation. These findings suggest a more general role for micro RNAs in gene regulation through the formation of RNA duplexes.
Keywords
Biochemistry, Genetics and Molecular Biology
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