Rapid Telomere Shortening in Children
BloodPublished 1 May 1999
Steven L. Zeichner, Paul Palumbo, Yanru Feng, Xiaodong Xiao, Dennis Gee, John W. Sleasman
Citations178
SJR quartileQ1
SJR score5.82
SNIP3.47
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TL;DR
Results show that the rate of telomere loss changes during ontogeny, suggesting the existence of periods of accelerated cell division in children, and may provide an explanation for some of the distinctive pathogenic features of the HIV disease in infants.
Abstract
Telomere shortening may reflect the total number of divisions experienced by a somatic cell and is associated with replicative senescence. We found that the average rate of telomere shortening in peripheral blood mononuclear cells (PBMCs) obtained longitudinally from nine different infants during the first 3 years of life (270 bp per year) is more than fourfold higher than in adults and does not correlate with telomerase activity. These results show that the rate of telomere loss changes during ontogeny, suggesting the existence of periods of accelerated cell division. Because human immunodeficiency virus (HIV) preferentially infects actively dividing cells, our observation suggesting accelerated cell division in children may provide an explanation for some of the distinctive pathogenic features of the HIV disease in infants, including higher viral loads and more rapid progression to acquired immunodeficiency syndrome (AIDS).
Keywords
Medicine
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