Cardiovascular autonomic neuropathy (expiration and inspiration ratio) in type 1 diabetes
Journal of Diabetes and its ComplicationsPublished 1 January 2000
Péter Stella, Demetrius Ellis, Raelene E. Maser, Trevor J. Orchard
Citations80
SJR quartileQ2
SJR score1.05
SNIP0.97
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TL;DR
It is concluded that beyond age and poor glycemic control, nephropathy is a significant risk factor for CAN and this association may explain some of the increased mortality seen in CAN.
Abstract
The pathogenesis of diabetic neuropathy is poorly understood. In this prospective study, we investigated the incidence rate and potential predictors for cardiovascular autonomic neuropathy (CAN) in a cohort of childhood-onset type 1 diabetic patients. Subjects from the Epidemiology of Diabetes Complications Study were examined at baseline and then biennially. CAN was diagnosed by abnormal (200 ug/min) (RR=2.46, p=0.0001) to be significant independent predictors. Hypertension was, however, predictive if nephropathy was not included in the model. We conclude that beyond age and poor glycemic control, nephropathy is a significant risk factor for CAN and this association may explain some of the increased mortality seen in CAN.
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