Involvement of leukocytes in the oxygenation and chlorination reaction of phenylbutazone
Biochemical PharmacologyPublished 1 November 1986
Shigeyasu Ichihara, Hiroki Tomisawa, Hideo Fukazawa, Mitsuru Tateishi, Raymond Joly, R. Heintz
Citations33
SJR quartileQ1
SJR score1.60
SNIP1.24
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TL;DR
A center carbon atom of 1,3-diketone moiety of phenylbutazone was oxidized to give three metabolites by the action of enzymes present in leukocyte extract obtained from peritoneal exudate of rats.
Abstract
A center carbon atom of 1,3-diketone moiety of phenylbutazone was oxidized to give three metabolites--4-hydroxyphenylbutazone (metabolite I), 4-hydroperoxyphenylbutazone (metabolite II) and 4-chlorophenylbutazone (metabolite III)--by the action of enzymes present in leukocyte extract obtained from peritoneal exudate of rats. Both metabolites II and III were produced by peroxidases, while metabolite I was produced by enzymes other than the peroxidases.
Keywords
Pharmacology, Toxicology and Pharmaceutics
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