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Effect of Antiserum and Antibiotics on Persistent Infection of HeLa Cells with Meningopneumonitis Virus

The Journal of ImmunologyPublished 1 April 1961Open access
Gennaro Galasso, G. P. Manire
Citations45
SJR quartileQ1
SJR score1.43
SNIP0.82
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TL;DR

The effect of antiviral agents on a persistent infection of HeLa cells with meningopneumonitis virus has been studied and tetracycline appears to have an in vitro effect on the virus.

Abstract

Summary The effect of antiviral agents on a persistent infection of HeLa cells with meningopneumonitis virus has been studied. Antiserum does not appear to have a significant effect. Penicillin, even when treatment is prolonged for 3 ½ months, causes a drop in titer but does not completely remove the virus. Chloramphenicol treatment for 21 days and tetracycline for 14 days are sufficient to remove all traces of virus. Tetracycline appears to have an in vitro effect on the virus.

Keywords

Immunology and MicrobiologyMedicine