Ovine maternal and fetal renal vasopressin receptor response to maternal dehydration
American Journal of Obstetrics and GynecologyPublished 1 December 1992
Linda K. Kullama, Michael Ross, Robert Lam, Rosemary D. Leake, M. Gore Ervin, Delbert A. Fisher
Citations13
SJR quartileQ1
SJR score2.77
SNIP2.75
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Specific, saturable, single-site tritiated arginine vasopressin binding is present in ovine maternal and fetal renal medullary membranes and does not down-regulate in response to dehydration-induced elevations in plasma arginin vasopressingin levels.
Abstract
Specific, saturable, single-site tritiated arginine vasopressin binding is present in ovine maternal and fetal renal medullary membranes. Ovine maternal and fetal renal arginine vasopressin receptors do not down-regulate in response to dehydration-induced elevations in plasma arginine vasopressin levels.
Keywords
PsychologyMedicine
Analytical BiochemistryA Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
225,378 Citations1976Mark A. Bradford
Analytical BiochemistryA rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
211,158 Citations1976Marion M. Bradford
Analytical BiochemistryLIGAND: A versatile computerized approach for characterization of ligand-binding systems
8,490 Citations1980Peter J. Munson, David Rodbard
This approach provides two major advantages compared with other available methods: it uses an exact mathematical model of the ligand-binding system, thereby avoiding the possible biases introduced by several commonly used approximations and it uses a statistically valid, appropriately weighted least-squares curve-fitting algorithm with objective measurement of goodness of fit.
American Journal of Physiology-Renal PhysiologyOsmotic and nonosmotic control of vasopressin release
502 Citations1979Robert W. Schrier, T. Berl +1 more
A model of osmotic and nonosmotic interactions, based on available electrophysiologic studies, is presented and its clinical implications are discussed.
Current topics in membranes and transportVasopressin Isoreceptors in Mammals: Relation to Cyclic AMP-Dependent and Cyclic AMP-Independent Transduction Mechanisms
146 Citations1983Serge Jard
The primary involvement of a rise in cytosolic cell calcium in the glycogenolytic response of hepatocytes and in the contractile response of vascular smooth muscle cells to vasopressin is established.
PeptidesCharacterization and localization of 3H-arginine8-vasopressin binding to rat kidney and brain tissue
116 Citations1983Daniel M. Dorsa, Lisa A. Majumdar +3 more
The present study presents the first anatomical evidence for the presence of AVP specific binding sites which might mediate this effect, and characterized AVP binding to membrane and tissue slice preparations from brain and kidney.
Australian Journal of Agricultural ResearchWater and electrolyte changes in tropical Merino sheep exposed to dehydration during summer
87 Citations1961W. V. Macfarlane, RJH Morris +3 more
The chance of survival in dehydration appears to be increased by low rates of water loss in the first 3 days, together with high sodium and low potassium excretion, and in rapid dehydration, more sodium was excreted than potassium and there was reduced sodium excretion when water was ingested after dehydration.
Molecular and Cellular EndocrinologyOntogenic development of antidiuretic hormone receptors in rat kidney: Comparison of hormonal binding and adenylate cyclase activation
87 Citations1976Rabary M. Rajerison, Daniel Butlen +1 more
The development of adenylate cyclase responsiveness to vasopressin and parathyroid hormone was studied using membrane fractions prepared from medullo-papillary and cortical portions of kidneys of 2-46-day-old rats.
European Journal of PharmacologyAutoradiographic localization of V1 vasopressin binding sites in rat brain and kidney
82 Citations1989Rüdiger Gerstberger, Falk Fahrenholz
In addition to renal cortical and medullary [3H]AVP binding sites, Medullary tubular and vascular structures could be labeled with the V1 antagonist, indicating the presence of both V1 and V2 AVP receptor subtypes in the rat kidney.
Pediatric ResearchDevelopmental Aspects of Renal Tubular Reabsorption of Water in the Lamb Fetus
77 Citations1979J Robillard, James R. Matson +2 more
The increase in Uosm in near-term fetuses suggests that the increase in free water reabsorption by theNear-term fetal kidney may represent either an increase in end-organ responsiveness to arginine vasopressin or maturation of mechanisms involved in the buildup of the osmotic gradient in the fetal medulla.
American Journal of Physiology-Renal PhysiologyVasopressin responsiveness of renal adenylate cyclase in newborn rats and rabbits
68 Citations1978Detlef Schlöndorff, Herbert Weber +2 more
It is intriguing to speculate that the low vasopressin stimulation of the medullary adenylate cyclase in the developing kidney may contribute to the known limitations of the urinary concentrating mechanism in the newborn period.
American Journal of Physiology-Renal PhysiologyContribution of vasopressin to the maintenance of blood pressure during dehydration
59 Citations1983Robyn L. Woods, C. I. Johnston
The results suggest that both the antidiuretic and vasoconstrictor properties of vasopressin are important in the cardiovascular response to dehydration, and that Brattleboro rats infused with exogenous arginine vasoppressin are able to maintain normal blood pressure during 48 h of dehydration.
Quarterly Journal of Experimental PhysiologyREGULATION OF URINE OSMOLALITY IN FETAL SHEEP
41 Citations1982E. Marelyn Wintour, D. P. Hennessy +2 more
Under conditions of in utero stress, hypertonic urine can be produced at lower endogenous plasma ADH concentrations than required to be established by infusion in non-stressed fetuses, suggesting that urinary concentrating mechanisms independent of ADH are established in these fetuses.
American Journal of Physiology-Cell PhysiologyRenal tubular vasopressin receptors downregulated by dehydration
40 Citations1988Matthew M. Steiner, M. Ian Phillips
It is concluded that physiologically elevated levels of AVP can downregulate vasopressin receptors in the kidney, which mediate the antidiuretic action of the hormone.
American Journal of Physiology-Endocrinology and MetabolismMaternal dehydration-rehydration: fetal plasma and urinary responses
29 Citations1988Michael G. Ross, D. Sherman +3 more
Fetal hyperosmolality, blood volume contraction, AVP secretion, and altered urine production in response to maternal dehydration are demonstrated and despite maternal rehydration and normalization of maternal and fetal plasma osmolality, fetal endocrine and fluid responses are prolonged.
PubMedDesign of neurohypophyseal peptides that exhibit selective agonistic and antagonistic properties.
27 Citations1977M. Manning, John Lowbridge +2 more
Analysis of the pharmacological data from over 300 analogs of oxytocin and vasopressin allows the delineation of those structural modifications that can optimize selectivities, and the potential and limitations of this approach for the design of peptides possessing desired agonistic or antagonistic selectivity are discussed.
American Journal of Obstetrics and GynecologyRenal effects of ovine fetal arginine vasopressin secretion in response to maternal hyperosmolality
16 Citations1986M.Gore Ervin, Michael G. Ross +3 more
Assessment of the effect of short-term changes in maternal osmolality on fetal arginine vasopressin secretion and renal function in six ewes found it possible to contribute to increased amniotic fluid o smolality in response to maternal hyperosmolality.
American Journal of Physiology-Regulatory, Integrative and Comparative PhysiologyOvine fetal renal and hormonal responses to changes in plasma epinephrine
3 Citations1991M. G. Ervin, Robert Castro +5 more
It is demonstrated that epinephrine infusion stimulates fetal ANF secretion and to a lesser extent AVP secretion and significantly influences fetal renal function.
