Comparison of the consensus sequence flanking translational start sites in<i>Drosophila</i>and vertebrates
Nucleic Acids ResearchPublished 1 January 1987Open access
Douglas R. Cavener
Citations963
SJR quartileQ1
SJR score7.78
SNIP4.71
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TL;DR
Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CAAAACAUG.
Abstract
The previously presented consensus sequence for eukaryotic translation initiation sites by Kozak was derived substantially from vertebrate mRNA sequences. Drosophila nuclear genes exhibit a significantly different translation start consensus sequence. These differences probably do not represent mechanistic differences in translation initiation inasmuch as both taxa exhibit identical preferences and restrictions at the crucial -3 position. Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CAAAACAUG.
Keywords
Biochemistry, Genetics and Molecular Biology
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