IgE responses in cats infected with Brugia pahangi
Parasite ImmunologyPublished 1 May 1993
C.I. Baldwin, F. Medeiros, D. A. Denham
Citations42
SJR quartileQ2
SJR score0.65
SNIP0.67
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
It is suggested that this specific IgE is actively involved in killing adult worms in the lymphatics in cats repeatedly infected with the filarial nematode Brugia pahangi.
Abstract
Passive cutaneous anaphylaxis tests were used to examine the IgE responses of cats repeatedly infected with the filarial nematode Brugia pahangi. Specific IgE was usually detected only in those cats that killed their adult worms and rarely in those cats in which adult worms survived for long periods. We suggest that this specific IgE is actively involved in killing adult worms in the lymphatics.
Keywords
MedicineEnvironmental Science
NatureHuman IgE, IgG4 and resistance to reinfection with Schistosoma haematobium
649 Citations1991Paul Hagan, U. J. Blumenthal +3 more
The results support the hypothesis that the slow build-up of IgE to high levels and the early production of IgG4 antibodies, which may block IgE pathways, are responsible for delaying the development of protective immunity to S. haematobium.
The Journal of PhysiologyVascular reactions to histamine, histamine‐liberator and leukotaxine in the skin of guinea‐pigs
538 Citations1952A. A. Miles, E. M. Miles
The present investigation is part of an attempt to prove an old hypothesis, namely, that this increase in permeability is mediated by histamine, and is confined to the skin of guinea-pigs.
Journal of Clinical PathologyHandbook of Experimental Immunology
431 Citations1988Denman Am
This is an enjoyable and readable account of the rheumatic diseases, and some of their opinions seem rather too immunological, especially concerning the pathogenesis of connective tissue disorders.
NatureSpecific IgE antibodies in immune adherence of normal macrophages to Schistosoma mansoni schistosomules
305 Citations1975A Capron, Jean‐Paul Dessaint +2 more
It is demonstrated conclusively that these antibodies have a protective role in man and similar reagin-type antibodies in animals, and the role of IgE antibodies in this case is unclear.
NatureElevation of total serum IgE in rats following helminth parasite infection
172 Citations1974Ellen E. E. Jarrett, Hervé Bazin
Infections with parasitic worms lead to the production of high levels of reaginic or IgE antibodies against parasite antigens, and greatly elevated levels of total IgE occur in most individuals infected with any one of a variety of helminths.
NatureReagin-like Antibodies in Animals Immune to Helminth Parasites
156 Citations1964Bridget Ogilvie
Investigations here have shown that rats, monkeys and sheep infected with helminth parasites produce an antibody with many of the properties of human reagin, but they are incapable of sensitizing guineapig skin in passive cutaneous anaphylaxis.
NatureAntibody-dependent cell-mediated damage to schistosomula in vitro
139 Citations1974A Butterworth, R. F. Sturrock +2 more
Two new aspects of cell-mediated responses to metazoan parasites are presented and it is provided that normal human peripheral blood leukocytes, in the presence of sera from patients infected with S. mansoni, can damage labelled schistosomula in the absence of added complement.
The Journal of ImmunologyIgE responses in human filariasis. I. Quantitation of filaria-specific IgE.
122 Citations1981R Hussain, Robert G. Hamilton +3 more
A noncompetitive solid phase radioimmunoassay to quantitate human IgE antibodies against soluble adult antigens of Brugia malayi, a filarial parasite, in sera of patients with various forms of clinical filariasis in Madras, India found high percentages of specific IgE may be responsible for evoking allergic symptomatology in patients with tropical pulmonary eosinophilia.
Advances in Parasitology/Advances in parasitologyBrugian Filariasis: Epidemiological and Experimental Studies
120 Citations1977D. A. Denham, P. B. McGreevy
The correlation between peak peripheral microfilaraemia and peak biting time suggests that filarial nematodes have adapted theirperiodicity patterns to vector periodicity patterns for facilitating their transmission by mosquitoes.
International Archives of Allergy and Applied ImmunologyNon-Specific Potentiation of IgE by Parasitic Infections in Man
83 Citations2009Keven J. Turner, Leonie Feddema +1 more
The observations suggest that parasitic infections in man as in laboratory animals potentiate the production of high levels of IgE with specificity unrelated to that of the parasite antigens.
Parasitology TodayReinfection, exposure and immunity in human schistosomiasis
71 Citations1992Paul Hagan
The results of the reinfection studies that have been completed on Schistosoma mansoni in Kenya and Brazil and on S. haematobium in The Gambia are focused on.
International Journal for ParasitologyStudies with Brugia pahangi—I. parasitological observations on primary infections of cats (Felis catus)
62 Citations1972D. A. Denham, T. Ponnudurai +3 more
The large majority of cats given a single inoculation of third stage larvae of Brugia pahangi became microfilaraemic and the recovery of adult worms was directly related to the number of larvae injected.
Journal of HelminthologyStudies with <i>Brugia pahangi</i> 4. Antibodies against adult and microfilarial stages
59 Citations1974T. Ponnudurai, D. A. Denham +2 more
Microfilarial antigen was ineffective in detecting antibody response in cats during the microfilaraemic phase of the infection, although it was possible to detect circulating antibody in cats which became microfilippia negative after repeated and prolonged reinfection and in one cat which after infection failed to show microfiliariae in its blood.
PubMed CentralQuantitative determination of specific IgE antibodies to schistosome antigens and serum IgE levels in patients with schistosomiasis (S. mansoni or S. haematobium)
59 Citations1975J.P. Dessaint, M Capron +2 more
Levels of IgE antibodies to schistosomal antigens were quantitatively measured for the first time, by the use of an immunosorbent technique, and correlated with overall serum IgE.
Parasitology TodayA model for the dynamics of human lymphatic filariasis
57 Citations1991Bryan T. Grenfell, E. Michael +1 more
The cat model provides an important tool for elucidating the relationships between infection, immunity and disease dynamics in lymphatic filariasis, and is suggested by suggesting directions for further work in this area.
Archives of DermatologyComparative Physiology and Pathology of the Skin
57 Citations1966Kenneth M. Halprin
This handsome book represents the contributions of 46 speakers at the first symposium on comparative dermatology held in April 1964 under the joint auspices of the School of Clinical Research and Postgraduate Medical Teaching and the Veterinary Medical School of the University of Cambridge.
International Journal for ParasitologyStudies with Brugia pahangi—II. The effect of repeated infection on parasite levels in cats
56 Citations1972D. A. Denham, T. Ponnudurai +3 more
In most cats the microfilarial levels increased considerably but in a minority the levels remained the same as those seen in cats given only one infection, while after a long series of challenge infections, the microFilarial counts of some cats suddenly fell and the blood became free ofmicrofilariae.
Cellular ImmunologyThe IgE and IgG subclass responses of mice to four helminth parasites
44 Citations1989Sandra G.H. Zakroff, Lucinda Beck +2 more
PubMedDetection of circulating antigens and immune complexes in feline and human lymphatic filariasis.
28 Citations1981Au Ac, Denham Da +5 more
Both antigen tests were as sensitive as antibody tests, however, ELISA was likely to be affected by the presence of antiglobulins, such as rheumatoid factor, in the test sera.
Journal of HelminthologyStudies with<i>Brugia pahangi</i>7. Changes in lymphatics of injected cats
26 Citations1974Rosemary Rogers, D. A. Denham
In some long-term repeatedly infected cats, the lymphatics became non-functional fibrous cords and conditions of oedema and early elephantiasis, similar to those seen in early human filariasis, were produced.
International Archives of Allergy and Applied ImmunologyIgE-Dependent Killing of Brugia malayi Microfilariae by Human Platelets and Its Modulation by T Cell Products
25 Citations2009Véronique Pancré, Jean-Yves Cesbron +4 more
Platelets isolated from patients infected with filariasis were cytotoxic for microfilariae in vitro and platelets from normal donors acquired killing properties in the presence of serum from infected individuals.
Parasite Immunology<i>Brugia pahangi</i> infections in cats: antibody responses which correlate with the change from the microfilaraemic to the amicrofilaraemic state
25 Citations1986Courtney V. Fletcher, David Birch +2 more
The data suggest that selective recognition of antigens by some cats is responsible for the production of antibodies which may then promote microfilarial death.
ParasitologyRepeated infection of cats with<i>Brugia pahangi</i>: parasitological observations
23 Citations1992D. A. Denham, F. Medeiros +5 more
Cats were repeatedly inoculated with infective larvae of Brugia pahangi to show that in Group II cats the adult worms die and as the cats are resistant to the development of the continuing weekly inoculation of L3 no new adults can develop.
Parasite ImmunologyInfection of inbred and nude (athymic) rats with <i>Brugia</i> spp.
17 Citations1983J.K. Cruickshank, Kylie M. Price +3 more
The difference in patency rates between ‘nude’ and normal PVG rats supports the contention that the development of filarial infections is T lymphocyte dependent.
Cellular and Molecular Life SciencesAnaphylactic reaction in the cat following intraventricular and intravenous injections of antigen
17 Citations1969Branislav D. Janković, Lj. Rakić +2 more
Laγ-globuline bovine, en injections intraveineuses et dans le ventricule latéral du cerveau, a produit, chez le chat, l'apparition d'anticorps spécifiques dans the circulation and the sensibilisation déterminant une réaction anaphylactique d'intensité variable.
Parasitology ResearchDetection of antibodies inBrugia pahangi-infected cats by counter immunoelectrophoresis, indirect fluorescent antibody test and enzyme-linked immunosorbent assay
7 Citations1982Arstila Au, D. A. Denham +1 more
Using various homologous antigens, IFAT was found to be more sensitive than counter immunoelectrophoresis and ELISA in the detection of antibodies in the infected cats.
Journal of ParasitologyMicrofilariae of Brugia pahangi in the Blood of Cats Have Variable Levels of Feline IgG on Their Sheaths
7 Citations1989U N Premaratne, R. M. E. Parkhouse +1 more
Feline IgG was found on the sheath of microfilariae (mf) of Brugia pahangi isolated from the blood of cats, suggesting that the molecule is intact.
Parasite ImmunologyCirculating filarial antigen in cats infected with <i>Brugia pahangi</i> is indicative of the presence of adult worms
5 Citations1991H. Kumar, C.I. Baldwin +5 more
Antigen was detected consistently in a cat that was amicrofilaraemic but at autopsy harboured only two or three adult worms, while some cats showed slowly declining numbers of microfilariae and, in these, circulating antigen declined before the number of microFilariae.
PubMedDetection of filarial antibodies in Malayan and Bancroftian filariasis by the indirect fluorescent antibody test, using different filarial antigens.
2 Citations1982Arstila Au, C. C. Draper +4 more
Indirect fluorescent antibody tests (IFAT) using Wuchereria bancrofti infective larvae as antigen had the highest positivity rates in detecting Malayan and Bancroftsian filariasis as compared to IFAT using antigens prepared from 5 other animal filarial species.
Journal of ParasitologyThe Effect of Sera from Cats Infected with Brugia pahangi and Subsequently Treated with Levamisole on the Infectivity of Third-Stage Larvae of B. pahangi
1 Citations1988D. A. Denham, R Samad
Jirds autopsied at 33 days postmortem showed significant levels of parasitemia, contrary to reports of a previous study wherein serum from humans infected with B. malayi was found to induce cell adherence and death of the L3.
