Regeneration in Spinal Neurons: Proteosynthesis Following Nerve Growth Factor Administration
SciencePublished 6 May 1966
Donald M. Scott, E Gutmann, Peter Horsky
Citations38
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
Incorporation of H3-leucine into dorsal root ganglion cells in rats was markedly increased over that of controls following section of sciatic and femoral nerves and in animals which had received nerve growth factor after the operation.
Abstract
Incorporation of H(3)-leucine into dorsal root ganglion cells in rats was markedly increased over that of controls following section of sciatic and femoral nerves. Crush lesion of dorsal roots did not increase the H(3)-leucine uptake of these cells except in animals which had received nerve growth factor after the operation.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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The results obtained from ultra-violet microspectrography of the nucleic acid content of nerve cells have not been entirely satisfactory and it is still not known whether these changes are entirely degenerative in nature or are due to increased metabolic activity associated with increased synthesis of protein molecules.
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