Genetic Selection of Low Fertile Onchocerca volvulus by Ivermectin Treatment
PLoS neglected tropical diseasesPublished 30 August 2007Open access
Catherine Bourguinat, Sébastien D. S. Pion, Joseph Kamgno, Jacques Gardon, B. O. L. Duke, Michel Boussinesq
Citations111
SJR quartileQ1
SJR score1.37
SNIP1.44
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TL;DR
Ivermectin is causing genetic selection on O. volvulus, and this genetic selection is associated with a lower reproductive rate in the female parasites, which could have implications for the development of ivermECTin resistance in O.volvulus and for the ongoing onchocerciasis control programmes.
Abstract
The results indicate that ivermectin is causing genetic selection on O. volvulus. This genetic selection is associated with a lower reproductive rate in the female parasites. We hypothesize that this genetic selection indicates that a population of O. volvulus, which is more tolerant to ivermectin, is being selected. This selection could have implications for the development of ivermectin resistance in O. volvulus and for the ongoing onchocerciasis control programmes.
Keywords
MedicineEnvironmental Science
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