Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor.
Proceedings of the National Academy of SciencesPublished 1 January 1984
Janet Finer-Moore, R. M. Stroud
Citations512
SJR quartileQ1
SJR score3.41
SNIP2.38
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TL;DR
Knowing the three-dimensional structure of acetylcholine receptors is consistent with features of the model proposed and provides some constraints and prediction of a consensus secondary structure based on this analysis and on an empirical prediction method leads to a testable hypothesis about how the ion channel is formed and might function.
Abstract
Fourier analysis of the hydrophobicities of the acetylcholine receptor subunit sequences reveals regions of amphipathic secondary structure. Prediction of a consensus secondary structure based on this analysis and on an empirical prediction method leads to a testable hypothesis about how the ion channel is formed and might function. Knowledge of the three-dimensional structure of acetylcholine receptors is consistent with features of the model proposed and provides some constraints.
Keywords
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