Amnesia from ECS: The effect of pairing ECS and footshock

Psychonomic SciencePublished 1 January 1970Open access

John Jamieson, D.J. Albert

Citations15

TL;DR

This result shows that the “aftereffects” demonstrated by Schneider and Sherman are not general enough to account for all reported ECS-induced amnesia.

Abstract

An attempt was made to repeat the finding of Schneider & Sherman (1968) that apparent amnesia results from the pairing of footshock and ECS independently of passive-avoidance training. Pairing of footshock and ECS 5 h after training was not found to cause a retention deficit, whereas ECS immediately after training resulted in memory loss. This result shows that the “aftereffects” demonstrated by Schneider and Sherman are not general enough to account for all reported ECS-induced amnesia.

Keywords

PsychologyMedicineNeuroscience

ScienceTime-Dependent Processes in Memory Storage

1,456 Citations1966James L. McGaugh

The findings indicate that the long-lasting trace of an experience is not completely fixed, consolidated, or coded at the time of the experience, and that any search for the engram or the basis of memory is not going to be successful.

ScienceRetrograde Amnesia Produced by Electroconvulsive Shock after Reactivation of a Consolidated Memory Trace

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Rats had a memory loss of a fear response when they received an electroconvulsive shock 24 hours after the fear-conditioning trial and preceded by a brief presentation of the conditioned stimulus, which throws doubt on the assertion that electro Convulsive shock exerts a selective amnesic effect on recently acquired memories.

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ScienceAmnesia: A Function of the Temporal Relation of Footshock to Electroconvulsive Shock

192 Citations1968Allen M. Schneider, W. M. Sherman

When rats received a brief footshock upon stepping off an elevated platform, and an electroconvulsive shock 30 seconds or 6 hours afterward, amnesia was not observed 24 hours later, but if a second footshock (noncontingent) was delivered 0.5 second before the electro Convulsive shock,Amnesia was observed.

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Fish given a single electroconvulsive shock or intracranial administration of puromycin, acetoxycycloheximide, or KCl immediately following shock avoidance training show amnesia on retraining days later, while 24 hr after training no amnesia develops.

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Physiology & BehaviorEvidence supporting the memory disruption hypothesis of electro-convulsive shock action

18 Citations1969Gary Banker, Earl Hunt +1 more

A double foot-shock paradigm is used in a situation involving both passive avoidance and discriminated avoidance, and amnesia was observed when ECS followed seconds after training, in accord with the retrograde amnesia hypothesis.