Acute mountain sickness susceptibility, fitness and hypoxic ventilatory response

European Respiratory JournalPublished 1 September 1991Open access

JS Milledge, J. M. Beeley, James T. Broome, N.P. LUFF, Mary Pelling, James R. Smith

DOI10.1183/09031936.93.04081000

Source URL

Citations92

SJR quartileQ1

SJR score4.50

SNIP3.47

View PDF

TL;DR

In a party of 17 subjects who travelled together to 4,500 m, hypoxic ventilatory response (HVR) and maximum oxygen consumption (VO2max) were measured before departure and there was no correlation between AMS scores and HVR by either method of measurement.

Abstract

In a party of 17 subjects who travelled together to 4,500 m, hypoxic ventilatory response (HVR) and maximum oxygen consumption (VO2max) were measured before departure. HVR was measured under constant and varying alveolar carbon dioxide tension (PACO2) conditions. VO2max was measured by both standard expired gas collection technique on a treadmill and using the "shuttle run" technique. On arrival at altitude, symptoms of acute mountain sickness (AMS) were scored daily for three days. There were no cases of severe AMS but half of the party had mild to moderate degrees of AMS. There was no correlation between AMS scores and HVR by either method of measurement or with VO2max measured by either method of measurement or with VO2max measured by treadmill or shuttle run.

Keywords

MedicineBiochemistry, Genetics and Molecular Biology

European Journal of Applied PhysiologyA maximal multistage 20-m shuttle run test to predict $$\dot V$$ O2 max

1,215 Citations1982Luc A. L�ger, Jean Lambert

It is concluded that the 20-m shuttle run test is valid and reliable test for the prediction of the VO2 max of male and female adults, individually or in groups, on most gymnasium surfaces.

Journal of Applied PhysiologyVentilatory response to sustained hypoxia in normal adults

281 Citations1986Paul A. Easton, L. J. Slykerman +1 more

It is concluded that ventilatory response to hypoxia in adults is not sustained; it exhibits some biphasic features similar to the neonatal hypoxic response.

RespirationFluid Retention and Relative Hypoventilation in Acute Mountain Sickness

144 Citations2009Peter H. Hackett, Drummond Rennie +4 more

It is concluded that relative hypoventilation and weight gain appear early in the development of AMS suggesting links between altitude hypoxia, hyperventilation, hypocapnia, and the body's handling of water.

Journal of Applied PhysiologyIncreased carotid body hypoxic sensitivity during acclimatization to hypobaric hypoxia

144 Citations1987M Vízek, C. K. Pickett +1 more

It is suggested that acclimatization is associated with increased hypoxic ventilatory response accompanied by enhanced peripheral chemoreceptor responsiveness, which may contribute to the attendant rise in ventilation.

Journal of Applied PhysiologyLow acute hypoxic ventilatory response and hypoxic depression in acute altitude sickness

137 Citations1986Lorna G. Moore, G. L. Harrison +6 more

The hypoventilation in symptomatic compared to asymptomatic subjects was attributable both to a lower acute hypoxic response and a subsequent greater blunting of ventilation at high altitude.

PubMedPulmonary gas exchange in acute mountain sickness.

75 Citations1976J. R. Sutton, A. C. Bryan +6 more

These abnormalities in gas exchange suggest that the manifestations of cerebral and pulmonary dysfunction at altitude develop simultaneously, a finding that suggests coexisting cerebral andmonary edema at altitude.

European Respiratory JournalHypoxic ventilatory response and acute mountain sickness

47 Citations1988JS Milledge, PS Thomas +2 more

View PDF

Topics in environmental physiology and medicineChemoreflexive Ventilatory Response at Sea Level in Subjects With Past History of Good Acclimatization and Severe Acute Mountain Sickness

12 Citations1982Shu-tsu Hu, Shao-Yung Huang +2 more

Subjects with past histories of severe AMS were sought and assessed at sea level for their peripheral chemoreceptor sensitivity, with a parallel study on subjects who had been shown to acclimatize normally at altitude (well-acclimatized subjects).