The Connective Tissue Growth Factor/Cysteine- Rich 61/Nephroblastoma Overexpressed (CCN) Family*
Endocrine ReviewsPublished 1 April 1999Open access
David R. Brigstock
Citations562
SJR quartileQ1
SJR score9.18
SNIP8.84
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TL;DR
This work focuses on the regulation of Cellular Functions by the CCN Family and the structure of the Connective Tissue Growth Factor/Cysteine-Rich 61/Nephroblastoma Overexpressed family members.
Abstract
I. Introduction II. The Modular Structure of the Connective Tissue Growth Factor/Cysteine-Rich 61/Nephroblastoma Overexpressed (CCN) Family Members III. Connective Tissue Growth Factor (CTGF) A. Discovery B. Structure of the CTGF gene and protein C. CTGF mRNA production D. CTGF production, secretion, and processing E. CTGF-heparin interactions F. Biological properties of CTGF G. Mechanism of action of CTGF IV. Cyr61 A. Discovery of cyr61 B. Structure of the cyr61 gene and protein C. Cyr61 mRNA production D. Cyr61 production and secretion E. Biological properties of cyr61 F. Mechanism of action of cyr61 V. Nov A. Discovery and structure of nov B. Nov mRNA production C. Biological properties of nov VI. Elm1/WISP-1 VII. Heparin-Induced CCN-Like Protein (HICP)/rCop-1/CTGF-3/WISP-2 VIII. WISP-3 IX. Other CCN-Like Molecules X. Regulation of Cellular Functions by the CCN Family A. Cell cycle control B. Cell adhesion and migration C. Extracellular matrix (ECM) production XI. Biological Processes Involving the CCN...
Keywords
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102 Citations1998Devashish Kothapalli, Nobukazu Hayashi +1 more
Kinetic studies of the induction of DNA synthesis by CTGF in cells arrested by cAMP indicate that the block occurs in very late G1, and studies in monolayer cultures suggest that the CTGF restriction point in the cell cycle is distinct from the adhesion‐dependent arrest point.
The Journal of Clinical Endocrinology & MetabolismIdentification of Glycosylated 38-kDa Connective Tissue Growth Factor (IGFBP-Related Protein 2) and Proteolytic Fragments in Human Biological Fluids, and Up-Regulation of IGFBP-rP2 Expression by TGF-β in Hs578T Human Breast Cancer Cells
101 Citations1998Dong‐Hoon Yang, H.-S. Kim +3 more
The studies indicate that IGFBP-rP2 appears to be an important endocrine factor, and one of thecritical downstream effectors of the critical downstream effector of TGF-beta, similar to the role of IGF BP-3 in T GF-beta-induced growth inhibition in human breast cancer cells.
Biochemical and Biophysical Research CommunicationsDemonstration of Receptors Specific for Connective Tissue Growth Factor on a Human Chondrocytic Cell Line (HCS-2/8)
101 Citations1998Takashi Nishida, Tohru Nakanishi +6 more
The presence of receptors specific for connective tissue growth factor (CTGF) was demonstrated on a human chondrosarcoma-derived chondrocytic cell line, HCS-2/8, and findings suggest that CTGF directly binds to specific receptor molecules on HCS/8 cells.
Journal of Cellular PhysiologyAmphiregulin‐dependent proliferation of cultured human keratinocytes: Autocrine growth, the effects of exogenous recombinant cytokine, and apparent requirement for heparin‐like glycosaminoglycans
100 Citations1994Michael W. Piepkorn, Christine Lo +1 more
It is demonstrated that exogenous amphiregulin is an effective growth promoting factor with molar potency similar to that of epidermal growth factor and structure‐function studies indicate that the polymerization level, high sulfate group density, and possibly iduronic acid content of heparin‐like moieties correlate with their inhibitory activity.
Journal of Biological ChemistryExpression of biologically active recombinant keratinocyte growth factor. Structure/function analysis of amino-terminal truncation mutants.
99 Citations1993Dina Ron, Donald P. Bottaro +4 more
In vitro mutagenesis generated a series of KGF mutants with sequential deletions of the amino-terminal domain, which resulted in significantly reduced ability to stimulate KGF receptor tyrosine-kinase activity and DNA synthesis, although this mutant bound the receptor at high affinity.
Environmental Health PerspectivesCross talk between peptide growth factor and estrogen receptor signaling systems.
98 Citations1995D M Ignar-Trowbridge, M Pimentel +3 more
Some physiologic actions of peptide growth factors are dependent on ER, particularly growth factors, which are capable of eliciting ER-dependent activation of an ERE.
Biology of ReproductionCharacterization of 16- to 20-Kilodalton (kDa) Connective Tissue Growth Factors (CTGFs) and Demonstration of Proteolytic Activity for 38-kDa CTGF in Pig Uterine Luminal Flushings1
97 Citations1998DeAnna K. Ball, Gulnar A. Surveyor +5 more
Data suggest that bioactive 10- to 20-kDa CTGF proteins are generated in utero through limited proteolysis of the 38-k da CTGF primary translational product.
Journal of Cellular PhysiologyDifferential gene expression in migrating renal epithelial cells after wounding
94 Citations1995Shashi Singh Pawar, Sreedharan Kartha +1 more
Adenosine diphosphate, a potent stimulator of cell migration which enhances expression of u‐PA and PAI‐1 in nonwounded cultures, additively stimulates these genes after wounding and may thereby potentiate wound healing.
Kidney InternationalCalcium oxalate monohydrate crystals stimulate gene expression in renal epithelial cells
93 Citations1995Mary Hammes, John C. Lieske +3 more
The results suggest that COM crystal-mediated stimulation of specific genes in renal tubular cells may contribute to the development of interstitial fibrosis in hyperoxaluric states.
Nucleic Acids ResearchPromoter function and structure of the growth factorinducible immediate early gene<i>cyr</i>61
88 Citations1991Branko Latinkic, Timothy P.O Brien +1 more
It is concluded that the cyr 61 SRE functions as a serum response element and may account for the coordinate activation of cyr61 and c-fos.
British Journal of DermatologyExpression of fibrogenic cytokines in desmoplastic malignant melanoma
88 Citations1998Kubo, Kikuchi +5 more
The reaction of PDGF‐B ligand and CTGF toPDGF‐β receptor, in addition to the expression of bFGF, may contribute to the desmoplasia in DMM.
Molecular and Cellular BiologyTranscriptional Down Regulation of the <i>nov</i> Proto-Oncogene in Fibroblasts Transformed by p60 <sup>v-</sup> <i> <sup>src</sup> </i>
86 Citations1996Glen M. Scholz, Cécile Martinerie +2 more
The nov proto-oncogene is identified as one gene that is down regulated in chicken embryo fibroblasts transformed by p60v-src and its down regulation may contribute to cellular transformation by the v-src oncogene.
Biochemical JournalExpression of extracellular matrix molecules in human mesangial cells in response to prolonged hyperglycaemia
84 Citations1996Nadia Abdel Wahab, Katherine L. Harper +1 more
R reverse transcriptase PCR (RT-PCR) confirmed that decorin mRNA levels are greatly elevated and also showed increased transcription of the TGF-beta 1 gene in hyperglycaemic cultures, indicating a cell-specific response in mesangial cultures.
The ProstateExpression of the extracellular matrix signaling molecule Cyr61 is downregulated in prostate cancer
82 Citations1998Christian Pilarsky, U. Schmidt +7 more
Differential display PCR (DD‐PCR) was used to identify genes related to the development of prostate cancer and showed clear trends in prognosis and remission in men diagnosed with prostate cancer.
Journal of Cellular PhysiologyHeparin inhibition of autonomous growth implicates amphiregulin as an autocrine growth factor for normal human mammary epithelial cells
81 Citations1992Shiwei Li, Gregory D. Plowman +2 more
Data suggest that both AR and TGF‐α mRNA are produced in much greater abundance by normal HMECs than in tumor‐derived cells in culture, and that AR is an important autostimulatory factor for the growth of normal HM ECs.
Biochemical and Biophysical Research CommunicationsInduction of Subcutaneous Tissue Fibrosis in Newborn Mice by Transforming Growth Factor β—Simultaneous Application with Basic Fibroblast Growth Factor Causes Persistent Fibrosis
78 Citations1997Mikio Shinozaki, Shigeru Kawara +4 more
The in vivo effects of transforming growth factor-beta by injection into subcutaneous tissue of newborn mice succeeded in establishing an animal model of skin fibrotic disorders by the exogenous addition of growth factors, and this animal model will be useful for future studies in this area.
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