The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.
Genes & DevelopmentPublished 1 December 1995Open access
Carrie Baker Brachmann, Joyce M. Sherman, Scott E. Devine, Ewan Cameron, Lorraine Pillus, Jef D. Boeke
Citations607
SJR quartileQ1
SJR score4.00
SNIP1.43
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TL;DR
The discovery of four Saccharomyces cerevisiae homologs of the SIR2 silencing gene (HSTs), as well as conservation of this gene family from bacteria to mammals are reported, establishing new connections between silencing and these fundamental cellular processes.
Abstract
Genomic silencing is a fundamental mechanism of transcriptional regulation, yet little is known about conserved mechanisms of silencing. We report here the discovery of four Saccharomyces cerevisiae homologs of the SIR2 silencing gene (HSTs), as well as conservation of this gene family from bacteria to mammals. At least three HST genes can function in silencing; HST1 overexpression restores transcriptional silencing to a sir2 mutant and hst3 hst4 double mutants are defective in telomeric silencing. In addition, HST3 and HST4 together contribute to proper cell cycle progression, radiation resistance, and genomic stability, establishing new connections between silencing and these fundamental cellular processes.
Keywords
Biochemistry, Genetics and Molecular Biology
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