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Sex Differences in Glucocorticoid Sensitivity of Proinflammatory Cytokine Production After Psychosocial Stress

Psychosomatic MedicinePublished 1 November 2001
Nicolas Rohleder, Nicole C. Schommer, Dirk H. Hellhammer, Renate Engel, Clemens Kirschbaum
Citations275
SJR quartileQ2
SJR score1.00
SNIP0.84

TL;DR

Investigating the impact of psychosocial stress and HPA axis activation on the GC sensitivity of proinflammatory cytokine production in men and women demonstrates that despite similar free cortisol responses of men andWomen (studied in the luteal phase of their menstrual cycle) to psychossocial stress, gender may exert differential effects on the immune system by modulating GC sensitivity.

Abstract

These results demonstrate that despite similar free cortisol responses of men and women (studied in the luteal phase) to psychosocial stress, gender may exert differential effects on the immune system by modulating GC sensitivity of proinflammatory cytokine production.

Keywords

MedicineNeuroscience