Diabetes mellitus and pancreaticcancer mortality in a prospectivecohort of United States adults
Cancer Causes & ControlPublished 1 August 1998
Eugenia E. Calle, Terrell K. Murphy, Carmen Rodríguez, Michael J. Thun, Clark W. Heath
Citations145
SJR quartileQ2
SJR score1.18
SNIP0.91
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TL;DR
The small but persistent increased risk of death from pancreatic cancer, seen even when the diagnosis of diabetes preceded death by many years, supports the hypothesis that diabetes may be a true, albeit modest, risk factor for pancreaticcancer.
Abstract
The small but persistent increased risk of death from pancreatic cancer, seen even when the diagnosis of diabetes preceded death by many years, supports the hypothesis that diabetes may be a true, albeit modest, risk factor for pancreatic cancer.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Journal of the Royal Statistical Society Series B (Statistical Methodology)Regression Models and Life-Tables
39,259 Citations1972D. R. Cox
Diabetes CareOnset of NIDDM occurs at Least 4–7 yr Before Clinical Diagnosis
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New England Journal of MedicinePancreatic Carcinoma
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Although a fairly limited number of medically-related exposures including hormonal medications hospitalization and pregnancy-related events appear to be accurately recalled as demonstrated in the comparisons of self-reports with medical records recall of other medically- related exposures including diagnostic radiographs and history of specific chronic illnesses is not as good.
American Journal of Public HealthSelf-report and medical record report agreement of selected medical conditions in the elderly.
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Self-report by elderly individuals compares favorably with medical record report of medical conditions in an elderly population, although strength of agreement varied by condition.
New England Journal of MedicineDiabetes and the Risk of Pancreatic Cancer
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The authors were able efficiently and accurately to reject the many false-positive matches while maintaining a reasonable level of manual record review and death certificate acquisition, thus allowing for continued automated follow-up of this valuable cohort.
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324 Citations1991Hans‐Olov Adami, Joseph K. McLaughlin +5 more
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JNCI Journal of the National Cancer InstituteEpidemiology of Cancer of the Pancreas2
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PubMedPancreatic cancer is associated with impaired glucose metabolism.
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PubMedSelection, follow-up, and analysis in the American Cancer Society prospective studies.
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The organization and selection characteristics of the American Cancer Society's prospective studies are reviewed, and problems connected with the follow-up procedures are discussed.
JNCI Journal of the National Cancer InstituteRisk of Pancreatic Cancer Following Diabetes Mellitus: a Nationwide Cohort Study in Sweden
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