Interleukin-1, Inflammation and Disease
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TL;DR
The role of interleukin-1 in the immune response and pharmacological manipulation in inflammatory joint disease and dematologic disease is examined.
Abstract
List of Contributors. Preface. SECTION A: Introduction. Chapter 1 Fever: historical aspects (6 papers) (E. Atkins). Chapter 2 Was the original endogenous pyrogen interleukin-1 (1 paper) (C. A. Dinarello). SECTION B: Biochemistry of interleukin-1 . Chapter 3 Cloning and expression of interleukin-1 (7 papers) (U. Gubler, Anne O. Chua, D.K. Lugg), Chapter 4 Differential gene expression, synthesis, processing and release of interleukin-1alpha and interleukin-1beta (5 papers) (Y. Kobayashi, K. Matsushima, J. Oppenheim), Chapter 5 The interleukin-1 receptor and post-receptor events (Introduction) (S.K. Dower, S. Gillis and J.E. Simms), Chapter 6 Assay of Interleukin-1 (3 papers) (J.H. Gearing and R. Thorpe), Chapter 7 Mechanisms and mediators in inflammation (8 papers) (G.A. Higgs), Chapter 8 The role of interleukin-1 in the immune response (4 papers), (K. Muegge and S.K. Durum), Chapter 9 Interleukin-1 and the vascular endothelial cell in inflammation (6 papers) (D.O. Haskard), Chapter 10 Interleukin-1 and connective tissue (6 papers) (J. Saklatvala), Chapter 11 Regulatory interactions between interleukin-1, tumor necrosis factor, and other inflammatory mediators (3 papers) (W.E. Scales and S.L. Kunkel). SECTION C: Interleukin-1 and systematic inflammation . Chapter 12 Fever (10 papers) (C.A. Dinarello), Chapter 13 Acute phase proteins (11 papers), Chapter 14 Inflammatory activities of locally or systematically administered interleukin-1 (4 papers) (R. Pettipher and B. Henderson), Chapter 15 Neuroendocrine interactions with interleukin-1 in inflammation (5 papers) (H. Nakamura) Chapter 16 Interleukin-1 in inflammatory joint disease (3 papers) (G. Duff), Chapter 17 Interleukin-1 in dematologic disease (3 papers) (D.N. Saunder), Chapter 18 Oscular inflammation (6 papers) (P. Bhattacherjee and P.S. Kulkarni). SECTION D: Pharmacological manipulation of interleukin-1 . Chapter 19 (4 papers) (J-M Dayer and P. Seckinger), Chapter 20 Pharmacological manipulation of interleukin-1 synthesis, secretion or action (5 papers) (J.A. Schmidt, J. Rhodes and R. Bomford). Subject Index. Elsevier Imprint