Destruction of dopaminergic nerve terminals in nucleus accumbens: Effect on d-amphetamine self-administration
Pharmacology Biochemistry and BehaviorPublished 1 November 1979
William H. Lyness, N.M. Friedle, Kenneth E. Moore
Citations458
SJR quartileQ1
SJR score0.95
SNIP0.81
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TL;DR
Results suggest that dopaminergic nerve terminals in nucleus accumbens are necessary for both the acquisition and maintenance of d-amphetamine self-administration.
Abstract
Control rats initiate self-administration of d-amphetamine and achieve stable injection rates within 7-10 days. Rats in which dopamine nerve terminals in nucleus accumbens were destroyed by bilateral microinjections of 6-hydroxydopamine (6-OHDA) did not initiate self-administration of d-amphetamine when tested for as long as 19 days. In rats previously trained to self-administer d-amphetamine, 6-OHDA injections into nucleus accumbens abolished d-amphetamine self-administration. These results suggest that dopaminergic nerve terminals in nucleus accumbens are necessary for both the acquisition and maintenance of d-amphetamine self-administration.
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MedicineNeuroscience
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