Mothers' pelvic size, fetal growth, and death from stroke and coronary heart disease in men in the UK
The LancetPublished 1 November 1996
CN Martyn, DJP Barker, Clive Osmond
Citations387
SJR quartileQ1
SJR score12.11
SNIP22.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Stroke may originate in poor nutrition during the mother's childhood, which deforms the bony pelvis and subsequently impairs her ability to sustain the growth of the placenta and fetus in late pregnancy, leading to the hypothesis that the disease is programmed in fetal life.
Abstract
Stroke may originate in poor nutrition during the mother's childhood, which deforms the bony pelvis and subsequently impairs her ability to sustain the growth of the placenta and fetus in late pregnancy. Coronary heart disease, on the other hand, seems to originate in adaptations made by the fetus to inadequate delivery of nutrients when it occurs for reasons other than failure of placental growth.
Keywords
Medicine
BMJFetal origins of coronary heart disease
3,540 Citations1995D.J.P. Barker
The fetal origins hypothesis states that fetal undernutrition in middle to late gestation, which leads to disproportionate fetal growth, programmes later coronary heart disease.
The LancetWEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE
3,518 Citations1989David J.P. Barker, Clive Osmond +3 more
Measurements that promote prenatal and postnatal growth may reduce deaths from ischaemic heart disease and may be especially important in boys who weigh below 7.5 pounds (3.4 kg) at birth.
The LancetINFANT MORTALITY, CHILDHOOD NUTRITION, AND ISCHAEMIC HEART DISEASE IN ENGLAND AND WALES
2,871 Citations1986David J.P. Barker
Although the rise in ischaemic heart disease in England and Wales has been associated with increasing prosperity, mortality rates are highest in the least affluent areas.
The LancetFetal nutrition and cardiovascular disease in adult life
2,747 Citations1993David J.P. Barker, Keith M. Godfrey +4 more
This paper shows how fetal undernutrition at different stages of gestation can be linked to these patterns of early growth in babies who are small at birth or during infancy.
The LancetHAEMOSTATIC FUNCTION AND ISCHAEMIC HEART DISEASE: PRINCIPAL RESULTS OF THE NORTHWICK PARK HEART STUDY
1,956 Citations1986T W Meade, M Brozović +8 more
The Northwick Park Heart Study has investigated the thrombotic component of ischaemic heart disease by the inclusion of measures of haemostatic function, finding that the biochemical disturbance leading to IHD may lie at least as much in the coagulation system as in the metabolism of cholesterol.
New England Journal of MedicineFibrinogen as a Risk Factor for Stroke and Myocardial Infarction
1,658 Citations1984Lars Wilhelmsen, Kurt Svärdsudd +4 more
Although causality cannot be inferred from these data, it is possible that the fibrinogen level plays an important part in the development of stroke and myocardial infarction.
BMJEarly growth and death from cardiovascular disease in women.
823 Citations1993Clive Osmond, D J Barker +3 more
Relations between cardiovascular disease and birth weight are similar in men and women, and in men cardiovascular disease is also related to weight gain in infancy.
BMJRelation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years
731 Citations1996Hans Lithell, P. M. McKeigue +4 more
It is confirmed that reduced fetal growth is associated with increased risk of diabetes and suggest a specific association with thinness at birth and this relation seems to be mediated through insulin resistance rather than through impaired β cell function and to depend on an interaction with obesity in adult life.
Journal of HypertensionIs blood pressure inversely related to birth weight? The strength of evidence from a systematic review of the literature
729 Citations1996Catherine Law, Alistair W. Shiell
Blood pressure is inversely related to birth weight in children and in adults and the positive results in neonates and the inconsistency in adolescence may be related to the unusual growth dynamics during these phases of growth.
BMJThe relation of small head circumference and thinness at birth to death from cardiovascular disease in adult life.
709 Citations1993D J Barker, Clive Osmond +2 more
Findings show that reduced fetal growth is followed by increased mortality from cardiovascular disease, and suggest that reduction in growth begins early in gestation, further evidence that cardiovascular disease originates through programming of the body's structure, physiology, and metabolism by the environment during fetal life.
DiabetologiaThinness at birth and insulin resistance in adult life
708 Citations1994David I. W. Phillips, David J.P. Barker +3 more
It is concluded that insulin resistance is associated with impaired development in fetal life and men and women who were thin at birth, as measured by a low ponderal index, were more insulin resistant.
HeartGrowth in utero, adult blood pressure, and arterial compliance.
367 Citations1995C N Martyn, D.J.P. Barker +4 more
Impairment of fetal growth is associated with raised blood pressure in adult life and decreased compliance in the conduit arteries of the trunk and legs.
BMJRelation of fetal and infant growth to plasma fibrinogen and factor VII concentrations in adult life.
251 Citations1992D.J.P. Barker, T W Meade +5 more
Reduced growth in fetal life and infancy is strongly related to high plasma concentrations of the haemostatic factors fibrinogen and factor VII, which may be a persisting response to impaired liver development during a critical early period.
BMJDeath rates from stroke in England and Wales predicted from past maternal mortality.
158 Citations1987D.J.P. Barker, Clive Osmond
Geographical differences in maternal mortality in England and Wales during 1911-4 correlate closely with death rates from stroke in the generation born around that time, providing new evidence that poor health and physique of mothers are important determinants of the risk of stroke among their offspring.
British Journal of HaematologyPlasma concentrations of fibrinogen and factor VII in adult life and their relation to intra‐uterine growth
109 Citations1995C N Martyn, T W Meade +2 more
It is suggested that, in men, reduced growth of the liver in fetal life has a long‐term influence on fibrinogen metabolism, and this influence is related to weight and abdominal circumference at birth.
Journal of the American Medical AssociationA STUDY OF PELVIC TYPE
39 Citations1939William Greulich, Herbert Thoms +1 more
According to data compiled by Martin, 1 Negroes, Melanesians and Tasmanians are mesatipellic, while Bushwomen, Hottentots, Australians and Malays are dolichopellic.