A Review of Age Differences in the Neurophysiology of Nociception and the Perceptual Experience of Pain
Clinical Journal of PainPublished 1 January 2004
Stephen J. Gibson, Michael J. Farrell
Citations471
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SJR score0.86
SNIP1.08
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TL;DR
To better understand the nature of age differences in pain and nociception with the aging of the worlds’ population, a small, but demonstrable age-related impairment in the early warning functions of pain is suggested.
Abstract
The clinical implications are obvious; older persons are likely to be especially vulnerable to the negative impacts of pain and pain associated events.
Keywords
MedicineNeuroscience
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Neurochemical ResearchGlutamate-Glutamine Cycle and Aging in Striatum of the Awake Rat: Effects of a Glutamate Transporter Blocker
22 Citations2001Gregorio Segovia, Alberto Del Arco +2 more
The same profile glutamine/glutamate as in young rats was found in middle-aged, aged and very aged rats, which suggests that the action of glutamate on the glutamate-glutamine cycle in striatum of the awake rat is not modified as a consequence of aging.
Neuroscience ResearchReciprocal age-related changes in GAP-43/B-50, substance P and calcitonin gene-related peptide (CGRP) expression in rat primary sensory neurones and their terminals in the dorsal horn of the spinal cord and subintima of the knee synovium
18 Citations2002Mika Hukkanen, Louise A. M. Platts +4 more
Primary sensory neurones undergo age-related changes already in early stages of aging, aging may result in a reduction of substance P and C GRP axonal transport, and reduced numbers of CGRP containing synovial perivascular fibres may imply a deficient regulation of thesynovial microvasculature and therefore metabolic homeostasis of the joint in aged subjects.
Stereotactic and Functional NeurosurgeryAge-Dependent Changes of Short-Latency Somatosensory Evoked Potentials in Healthy Adults
18 Citations1988Georg Adler, A. C. Nacimiento
It is suggested that N20 and P27 are generated by different structures and that the subsequent components do not depend on P27, leading to the conclusion that short-latency somatosensory evoked potentials following median nerve stimulation in humans should not be concerned with.
Experimental Aging ResearchPhysostigmine-induced analgesia in young, middle-aged, and senescent rats
17 Citations1989Janet S. Knisely, Robert J. Hamm
Age-related differences in the analgesia produced by physostigmine is in agreement with other research which has demonstrated that pharmacological stimulation of the cholinergic system produces an equivalent or increased responsivity in aged animals.
Archives of Gerontology and GeriatricsCourse of pain sensitivity in aging: pathogenetical aspects of silent cardiopathy
13 Citations1997C Lucantoni, Stefano Marinelli +3 more
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