Leptin and the regulation of body weight
The International Journal of Biochemistry & Cell BiologyPublished 1 November 1997
Robert V. Considine, F. José
Citations230
SJR quartileQ2
SJR score0.97
SNIP0.77
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TL;DR
The current findings on leptin in both humans and rodents are summarized and the physiology and potential for pathophysiology in leptin-mediated regulation of body weight and composition are discussed.
Abstract
Leptin has received considerable attention as a newly recognized metabolic hormone and for its potential for therapeutic use in the treatment of human obesity. Furthermore, defects in the leptin signal pathway that result in obesity in animal models have raised the possibility of a similar etiology for obesity in humans. This review will summarize the current findings on leptin in both humans and rodents. These findings will be discussed with respect to our view of the physiology and potential for pathophysiology in leptin-mediated regulation of body weight and composition.
Keywords
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177 Citations1996Bei Zhang, Michael P. Graziano +13 more
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169 Citations1995Naohi Isse, Yoshihiro Ogawa +11 more
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168 Citations1996Karine Clément, Chad Garner +12 more
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165 Citations1996Frédéric Cumin, Hans-Peter Baum +1 more
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160 Citations1996Stephen G. Miller, Piet De Vos +6 more
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156 Citations1996Steven M. Haffner, Michael P. Stern +3 more
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151 Citations1996Danielle R. Reed, Yuan Chun Ding +4 more
Genotyped siblings from 78 families at markers flanking the human OB gene and found that some individuals with extreme obesity have an allelic variant of the OB gene, although other nearby genes could contribute to obesity in these families.
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149 Citations1995Yufang He, Hui Chen +2 more
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124 Citations1996René Devos, John Richards +7 more
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DiabetesEffect of Troglitazone on Leptin Production: Studies In Vitro and in Human Subjects
110 Citations1996John J. Nolan, Jerrold M. Olefsky +3 more
It appears that obese subjects are resistant to the effects of endogenously secreted leptin, as there was no significant change in fasting plasma leptin concentrations, despite a 40–50% reduction in fasting and postmeal plasma insulin concentrations.
Biochemical and Biophysical Research CommunicationsAutoradiographic Localization of Leptin Binding in the Choroid Plexus ofob/obanddb/dbMice
99 Citations1996Richard B. Lynn, Gaoyuan Cao +3 more
An autoradiographic study of the binding of leptin receptors in the brain found only in the choroid plexus which is located in the dorsal part of the third ventricle and lateral ventricles to further understand the sites and mechanism of action of leptin on brain centers regulating body weight.
EndocrinologyLocalization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice.
99 Citations1996Karl F. Malik, W. Scott Young
It is hypothesized that the binding of leptin to its site may cause the release or transport of uncharacterized factor(s) into the cerebral spinal fluid (CSF) to affect neuronal populations controlling feeding and metabolism.
Proceedings of the National Academy of SciencesReflections on STAT3, STAT5, and STAT6 as fat STATs.
95 Citations1996James Darnell
The reported results suggest how leptin, the recently discovered weight control hormone, may signal cells through its cognate receptor by activation of STATs, proteins that serve the dual function of signal transducers and activators of transcription in cells exposed to signaling polypeptides.
Journal of Clinical InvestigationEarly and late stimulation of ob mRNA expression in meal-fed and overfed rats.
91 Citations1996Robin B. Harris, T. G. Ramsay +2 more
It is suggested that a metabolic consequence of meal-feeding increases ob mRNA expression in the absence of increased food intake or weight gain, and there is a further increase in ob RNA expression once significant obesity is established.
Biochemical and Biophysical Research CommunicationsAugmented Expression of the obese Gene in the Adipose Tissue from Rats Fed High-Fat Diet
86 Citations1995Hiroaki Masuzaki, Yoshihiro Ogawa +4 more
It is demonstrated that the Ob gene expression is augmented in the adipose tissue in diet-induced obesity, thereby suggesting the pathophysiologic roles of the ob gene in acquired obesity.
Biochemical and Biophysical Research CommunicationsDevelopment of Radioimmunoassay for Human Leptin
84 Citations1996Kiminori Hosoda, Hiroaki Masuzaki +11 more
Findings indicate that leptin is secreted from the adipose tissue into the circulating blood as a large molecular form corresponding to recombinant leptin.
Journal of Biological ChemistryPharmacologic Manipulation of ob Expression in a Dietary Model of Obesity
83 Citations1996Sheila Collins, Richard S. Surwit
Results indicate that expression of the ob gene serves as a sensor of fat cell hypertrophy, independent of any effects on food intake, in a dietary model in which moderate obesity develops in response to fat.
Biochemical and Biophysical Research CommunicationsMutation Screening and Identification of a Sequence Variation in the Human OB Gene Coding Region
72 Citations1996Robert V. Considine, Eileen L. Considine +9 more
In the present study mRNA from the subcutaneous adipose tissue of 68 obese and 38 lean subjects was screened for mutations in the ob gene coding region, suggesting that defects in the Ob gene sequence itself are not the primary cause of obesity in humans.
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