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Effects of β-adrenergic blockade and stimulation on airways in normal subjects

Postgraduate Medical JournalPublished 1 March 1976Open access
G. W. Bradley, Å Henderson, R. J. Mills
Citations10
SJR quartileQ2
SJR score0.79
SNIP1.05
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TL;DR

Propranolol had negligible overall effect on central and peripheral airway properties in normal subjects, and it would appear that P-adrenergic activity has little measurable influence on peripheral airways in normal man at rest.

Abstract

Summary The effects of propranolol and salbutamol on conventional pulmonary function tests and closing volume have been studied in ten normal subjects. Propranolol and salbutamol had minor effects on measurements of airways resistance but had no effect on closing volume which is particularly sensitive to changes in peripheral airways. It was concluded that propranolol had negligible overall effect on central and peripheral airways properties in normal subjects, and it would appear that β-adrenergic activity has little measurable influence on peripheral airways in normal man at rest.

Keywords

Agricultural and Biological SciencesMedicine