Urinary S100B protein measurements: A tool for the early identification of hypoxic-ischemic encephalopathy in asphyxiated full-term infants
Critical Care MedicinePublished 1 January 2004
Diego Gazzolo, Emanuela Marinoni, Romolo Di Iorio, Matteo Bruschettini, Maria Katarzyna Borszewska-Kornacka, Mario Lituania
Citations87
SJR quartileQ1
SJR score2.12
SNIP2.15
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TL;DR
Longitudinal S100B protein measurements in urine soon after birth are a useful tool to identify which asphyxiated infants are at risk of hypoxic-ischemic encephalopathy and its possible neurologic sequelae.
Abstract
Longitudinal S100B protein measurements in urine soon after birth are a useful tool to identify which asphyxiated infants are at risk of hypoxic-ischemic encephalopathy and its possible neurologic sequelae.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Archives of NeurologyNeonatal Encephalopathy Following Fetal Distress
2,627 Citations1976Harvey B. Sarnat
Twenty-one neonates of over 36 weeks' gestation suffered perinatal asphyxia but not chronic hypoxia; three clinical stages of postanoxic encephalopathy were distinguished; persistence of stage 2 for more than seven days or failure of the EEG to revert to normal was associated with later neurologic impairment or death.
Trends in Biochemical SciencesThe S100 family of EF-hand calcium-binding proteins: functions and pathology
682 Citations1996Beat W. Schäfer, Claus W. Heizmann
Some functional aspects of EF-hand proteins are described, which have been found recently in different cellular compartments, which share a common Ca(2+)-binding motif.
StrokeS-100 protein and neuron-specific enolase in cerebrospinal fluid and serum: markers of cell damage in human central nervous system.
491 Citations1987Lennart Persson, Hans‐Göran Hårdemark +5 more
In stroke patients, the S-100 and neuron-specific enolase concentrations may reflect the extent of brain damage and could be useful in selecting patients with major stroke for more aggressive treatment during the acute phase.
PEDIATRICSInterventions for Perinatal Hypoxic–Ischemic Encephalopathy
464 Citations1997Robert C. Vannucci, Jeffrey M. Perlman
There is no uniform standard of care in the brain-oriented therapy of full-term newborn infants sustaining cerebral hypoxia–ischemia, and it remains for future research to uncover new and effective strategies for the neurologically compromised infant.
Acta PaediatricaChanging panorama of cerebral palsy in Sweden. VIII. Prevalence and origin in the birth year period 1991–94
453 Citations2001Bengt Hagberg, G Hagberg +2 more
This 8th Swedish population‐based cerebral palsy (CP) report comprises 241 children born 1991–94 and Probable aetiology was identified in 73% of preterm and 86% of term children.
Archives of Disease in Childhood Fetal & NeonatalPredictive value of early continuous amplitude integrated EEG recordings on outcome after severe birth asphyxia in full term infants.
409 Citations1995Lena Hellström‐Westas, I. Rosén +1 more
The aEEG seems to be a feasible technique for identifying infants at high risk of subsequent brain damage who might benefit from interventionist treatment after asphyxia, and can predict outcome, with a high degree of accuracy, within the first six hours after birth.
Journal of NeurochemistryS100β Induces Neuronal Cell Death Through Nitric Oxide Release from Astrocytes
334 Citations1997Jingru Hu, Adriana Ferreira +1 more
The data support the idea that overexpression of S100β may be an exacerbating factor in the neurodegeneration of Alzheimer's disease.
PEDIATRICSIntrapartum Asphyxia and Cerebral Palsy
272 Citations1988John M. Freeman, Karin B. Nelson
To attribute cerebral palsy to prior asphyxia with reasonable certainty, there must be evidence that a substantial hypoxic injury occurred and that a sequence of events ensued which would prove the clinical impact of that hypoxic insult.
Journal of Cardiothoracic and Vascular AnesthesiaElimination of S100B and renal function after cardiac surgery
257 Citations2000Henrik Jönsson, Per Johnsson +3 more
The elimination of S 100B after cardiac surgery is faster than reported earlier and not affected by a moderate decrease in GFR, which is important when evaluating S100B levels after cardiac Surgery.
Pediatric ResearchEarly Biochemical Indicators of Hypoxic-Ischemic Encephalopathy after Birth Asphyxia
198 Citations2001Nicole Nagdyman, Wolfgang Kömen +3 more
It is concluded that elevated serum concentrations of protein S-100 and CK-BB reliably indicate moderate and severe HIE as early as 2 h after birth.
Neurochemical ResearchCa2+-Binding S100 Proteins in the Central Nervous System
133 Citations1999Claus W. Heizmann
This chapter will focus on the S100B and S100A6 proteins, which are highly expressed in the central nervous system, and their protein structures, localizations, and association with brain pathology as well as their potential use in clinical diagnostics will be discussed.
New England Journal of MedicineMeasurement of the Urinary Lactate:Creatinine Ratio for the Early Identification of Newborn Infants at Risk for Hypoxic–Ischemic Encephalopathy
129 Citations1999Chao Huang, Shan‐Tair Wang +3 more
Measurement of the urinary lactate: creatinine ratio soon after birth may help identify infants at high risk for hypoxic-ischemic encephalopathy.
Clinical ChemistryS100B Protein in Biological Fluids: A Tool for Perinatal Medicine
129 Citations2002Fabrizio Michetti, Diego Gazzolo
S100B protein appears to satisfy the criteria for a marker for brain injuries in perinatal medicine: simple to perform measurements with good reproducibility, detection in a variety of biological fluids, and possible use in longitudinal monitoring because of its 1-h half-life.
Journal of the Neurological SciencesThe S-100 antigen in cerebrospinal fluid as a possible index of cell injury in the nervous system
126 Citations1980Fabrizio Michetti, A. R. Massaro +2 more
The presence of the nervous system-specific S-100 antigen has been tested by microcomplement fixation assay with a monospecific anti-S-100 antiserum in cerebrospinal fluid of subjects suffering from psychiatric disorders or various neurological diseases.
Neuroscience LettersThe nervous system-specific S-100 antigen in cerebrospinal fluid of multiple sclerosis patients
96 Citations1979Fabrizio Michetti, A. R. Massaro +1 more
The nervous system-specific S-100 antigen has been found in cerebrospinal fluid of 13 out of 18 patients with multiple sclerosis, whereas it was undetectable in either of the 11 control patients with minor psychic disturbances or with neurological disorders not usually associated with apparent parenchymal lesion.
Brain ResearchS-100β stimulates neurite outgrowth in the rat sciatic nerve grafted with acellular muscle transplants
91 Citations1997Kenneth G. Haglid, Qiner Yang +4 more
It is demonstrated here that local administration of S-100beta stimulates the sciatic nerve regeneration into acellular muscle grafts and the results suggest that S- 100beta is a physiological growth factor for peripheral nerve axons.
Journal of NeurochemistryCharacterization of Human Brain S100 Protein Fraction: Amino Acid Sequence of S100β
90 Citations1985Roy A. Jensen, Daniel R. Marshak +3 more
It is document that S100β is a conserved protein among mammals and provide the necessary foundation for current clinical studies.
Archives of Disease in ChildhoodCerebral blood flow velocity variability in infants receiving assisted ventilation.
90 Citations1987Janet M. Rennie, Mike South +1 more
Variability of cerebral blood flow velocity was significantly greater when the infants were breathing out of synchrony with the ventilator than when they were either apnoeic, or breathing synchronously with theventilator, and was greatest within 12 hours of birth after which it fell progressively over the next 48 hours.
Journal of the Neurological SciencesElevated S100 blood level as an early indicator of intraventricular hemorrhage in preterm infants
89 Citations1999Diego Gazzolo, Paola Vinesi +6 more
The present data show that S100 blood concentrations offer a measurable parameter of brain lesion in preterm infants before a radiological assessment of hemorrhage can be performed, when clinical symptoms may be silent and preventive/therapeutic action could be especially useful.
Pediatric ResearchCirculating S100β Protein Is Increased in Intrauterine Growth-Retarded Fetuses
87 Citations2002Diego Gazzolo, Emanuela Marinoni +4 more
Evidence is provided that circulating S100β protein is increased in IUGR fetuses and correlates with cerebral hemodynamics, suggesting that it may represent an index of cerebral cell damage in the perinatal period.
Clinical ChemistryS100B Protein Concentrations in Cord Blood: Correlations with Gestational Age in Term and Preterm Deliveries
84 Citations2000Diego Gazzolo, Paola Vinesi +6 more
This study investigated the relationship between S100B concentrations in cord blood and gestational age in the third trimester of pregnancy in normal preterm and term deliveries in 58 women with consecutive singleton physiological pregnancies.
Critical Care MedicineS100B protein is increased in asphyxiated term infants developing intraventricular hemorrhage
79 Citations2002Diego Gazzolo, Romolo Di Iorio +5 more
This study suggests that elevated S100B protein represents a useful tool for the early detection of intraventricular hemorrhage in the postasphyxia period when clinical examination and cerebral ultrasound might still be silent.
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular EnzymologyPurification, characterization and ion binding properties of human brain S100b protein
57 Citations1984Jacques Baudier, Nicole Glasser +2 more
Results suggest that Zn2+ may regulate Ca2+ binding by increasing the affinity of the protein for calcium and cast doubt on the conservation of the S100 structure during evolution.
Acta PaediatricaChanges in Doppler ultrasonography in asphyxiated term infants with hypoxic‐ischaemic encephalopathy
56 Citations1998Pilvi Ilves, R. Talvik +1 more
It is concluded that severe post‐hypoxic increase of mean cerebral blood flow velocity at the age of 12 ± 2 h is connected with development of severe stage HIE and poor prognosis.
Clinical ChemistryS100B Protein Concentrations in Urine Are Correlated with Gestational Age in Healthy Preterm and Term Newborns
50 Citations2001Diego Gazzolo, Matteo Bruschettini +4 more
This study investigated whether S100B can be detected in urine of preterm and term infants and enrolled eighty-three women with normal physiological pregnancies.
Clinical ChemistryS100 Blood Concentrations in Children Subjected to Cardiopulmonary By-Pass
48 Citations1998Diego Gazzolo, Paola Vinesi +6 more
The data presented indicate significantly higher blood concentrations of this nervous tissue constituent during cardiopulmonary by-pass (CPB), together with a direct relationship with the duration of CPB.
Immunological InvestigationsNeonatal Anemia: Pathophysiology and Treatment
39 Citations1995Ronald G. Strauss
Obstetrics and GynecologyOntogenetic localization and distribution of S-100β protein in human placental tissues
36 Citations2002Emanuela Marinoni
It is demonstrated that fetoplacental tissues contain S‐100β protein, suggesting that these tissues may, at least in part, be responsible for the high level found in the fetal circulation.
Seminars in PerinatologyAn international network for evaluating neuroprotective therapy after severe birth asphyxia
36 Citations1999Malcolm I. Levene, David J Evans +2 more
Animal studies have shown great promise in their applicability to potentially neuroprotective therapies for severe birth asphyxia in human babies, but it is now necessary to consider a strategy to evaluate some or all of these techniques within the context of human neonatal randomized control trials (RCT).
Archives of Disease in Childhood Fetal & NeonatalS100 protein content of umbilical cord blood in healthy newborns in relation to mode of delivery
19 Citations2002J W Wirds, A E J Duyn +8 more
More research is necessary to determine whether S100 protein is a useful marker in neonatal asphyxia, and to relate S100protein concentrations in cord blood to mode of delivery.