FOS expression in orexin neurons following muscimol perfusion of preoptic area
NeuroreportPublished 1 May 2004
Shinsuke Satoh, Hitoshi Matsumura, Atsuko Fujioka, Tomoko Nakajima, Takashi Kanbayashi, Seiji Nishino
Citations17
SJR quartileQ3
SJR score0.49
SNIP0.39
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TL;DR
These results suggest that subpopulations of the preoptic neurons give an inhibitory tone to the activities of the orexin neurons in the perifornical/lateral hypothalamic areas.
Abstract
Unilateral microdialysis-perfusion of the preoptic area with 50 microM muscimol decreased the sleep period of rats to less than 3% of the baseline value over a 90 min period before death (p = 0.018 by Wilcoxon signed-rank test). These rats showed the expression of FOS in 36% of the orexin neurons located in the perifornical/lateral hypothalamic areas on the side ipsilateral to the perfusion site, but in only 3% of the orexin neurons on the side contralateral to it (p = 0.018 by Wilcoxon signed-rank test). These results suggest that subpopulations of the preoptic neurons give an inhibitory tone to the activities of the orexin neurons in the perifornical/lateral hypothalamic areas.
Keywords
PsychologyNeuroscience
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