Primary neurons maintain their central axonal arbors in the spinal dorsal horn following peripheral nerve injury: an anatomical analysis using transganglionic transport of horseradish peroxidase

It is demonstrated that primary neurons of all sizes survive following the transection and capping of their peripheral processes in the superficial radial nerve and maintain their synaptic vesicles, some of their synaptic connections and their ability to transport horseradish peroxidase transganglionically.

Abstract

This study in adult cats demonstrates that primary neurons of all sizes survive following the transection and capping with a polyethylene tube of their peripheral processes in the superficial radial nerve. The central axonal arbors of these injured primary neurons remain intact and maintain their normal topographic position across laminae I–VI of the cervical (C6–C8) dorsal horn. In addition, they maintain their synaptic vesicles, some of their synaptic connections and their ability to transport horseradish peroxidase transganglionically.