The effects of zidovudine in the subset of infants infected with human immunodeficiency virus type-1 (Pediatric AIDS Clinical Trials Group Protocol 076)
The Journal of PediatricsPublished 1 June 1999
George McSherry, David E. Shapiro, Robert W. Coombs, Nuala McGrath, Lisa M. Frenkel, Paula Britto
Citations31
SJR quartileQ1
SJR score1.01
SNIP1.11
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TL;DR
Zidovudine therapy during pregnancy and labor and in the neonatal period for 6 weeks failed to have a major effect on rapid progression of disease, timing of transmission, and viral replication in HIV-infected infants, and resistance to zidovUDine did not develop during study treatment.
Abstract
Our study supports the safety of zidovudine use in pregnancy and in the newborn period but demonstrates the continued need for more potent antiretroviral treatment of the infected infant.
Keywords
Immunology and MicrobiologyMedicine
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