Lactate-Induced Anxiety: Therapeutic Application
The British Journal of PsychiatryPublished 1 October 1971Open access
J.A. Bonn, Jean Harrison, W. Linford Rees
Citations91
SJR quartileQ1
SJR score2.47
SNIP2.17
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PsychologyMedicineNeuroscience
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There may be something highly specific about lactate ion in producing the naturally occurring hypocalcaemic anxiety symptoms in human beings.
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Pitts and McClure's Theory and Experiment reasoned that lactate ion accumulates in excessive amounts, more than the normal percentage of ionized calcium becomes complexed with lactate, and when the remaining free ions become reduced to clinically significant low concentrations, there will be interference with normal nerve conduction and activity.
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It is concluded that the increase in blood lactate concentration attributable to hyperventilation is comparatively small in exercise tests involving short periods of moderately severe exertion as normocapnichyperventilation was associated with virtually no change inBlood lactate and pyruvate concentrations.
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Intravenous infusion of dl-sodium lactate induces hypophosphataemia in man and β-Adrenergic blockade with propranolol does not prevent this fall in plasma phosphate.
