Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes
New England Journal of MedicinePublished 19 November 2008Open access
Valeriya Lyssenko, Anna Jonsson, Peter Almgren, Nicolò Pulizzi, Bo Isomaa, Jaakko Tuomilehto
Citations931
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR
Variants in 11 genes were significantly associated with the risk of type 2 diabetes independently of clinical risk factors; variants in 8 of these genes were associated with impaired beta-cell function.
Abstract
As compared with clinical risk factors alone, common genetic variants associated with the risk of diabetes had a small effect on the ability to predict the future development of type 2 diabetes. The value of genetic factors increased with an increasing duration of follow-up.
Keywords
Biochemistry, Genetics and Molecular Biology
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