Mecamylamine: new therapeutic uses and toxicity/risk profile
Clinical TherapeuticsPublished 1 April 2001
J.M. Young
Citations97
SJR quartileQ1
SJR score0.98
SNIP1.02
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TL;DR
The available data concerning potential new applications of mecamylamine, although sparse, suggest that the drug's toxicity/risk profile may be much improved at lower doses.
Abstract
The available data concerning potential new applications of mecamylamine, although sparse, suggest that the drug's toxicity/risk profile may be much improved at lower doses.
Keywords
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43 Citations1998Tony P. George, Christopher D. Verrico +1 more
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PubMedWithdrawal from nicotine dependence using mecamylamine: comparison of three-week and six-week dosage schedules.
21 Citations1984Tennant Fs, Tarver Al
Although MCL's numerous side-effects should limit its clinical use to recalcitrant smokers who have failed other types of treatment, its nicotine antagonist property indicates it can be an effective agent to withdraw some persons from nicotine dependence.
PubMedThe effect of reserpine and mecamylamine on experimental atheromatosis in the normotensive and hypertensive rat.
19 Citations1962Smith Th, Rossi Gv
Although the mechanism of the hypocholesterolemic effect of reserpine and mecamylamine remains to be established, it appears to be independent of their hypotensive activity and not attributable to changes in either the dietary intake, endogenous synthesis or absorption of cholesterol.
AddictionOverview: Biological processes relevant to drugs of dependence
15 Citations1994Neil E. Grunberg
Five papers that address biological processes underlying the actions of opiates, CNS stimulants, nicotine, alcohol, and benzodiazepines find that positive and negative reinforcement are common processes underlying actions of drugs of dependence.
Journal of NutritionThe Effects of Small Intestinal Colonization by Fecal and Colonic Bacteria on Intestinal Function in Rats
15 Citations1978Fima Lifshitz, Raul A. Wapnir +3 more
It is suggested that non-invasive enteric proliferation of colonic and fecal bacterial anaerobes in rats may be associated with deconjugation of bile salts, ultrastructural alterations of the intestinal epithelial cells, and a diminished jejunal transport capacity of carbohydrates and other solutes.
International Journal of NeuroscienceCholinergic mechanisms in gilles de la tourette's syndrome
13 Citations1995Reuven Sandyk
It is proposed that the emergence of motor and vocal tics in GTS is associated with increased central cholinergic activity, and abnormalities of the Cholinergic system support previous evidence linking GTS with delayed cerebral maturation in a subset of young patients.
Cellular and Molecular Life SciencesHypotensive and Ganglion blocking action of methyl substituted 3-amino-norcamphanes
13 Citations1958K. Rubinstein, J. G. A. Pedersen +2 more
5 Methyl-substituierte 3-Amino-norcamphane wurden im Vergleich zu 3-Methylamino-isocamphan in bezug auf Blockierung der Synapsen der autonomen Nervensysteme und blutdrucksenkenden Wirkung im narkotisierten Tier untersucht.
PubMedEffects of enteric microbial overgrowth on small intestinal ultrastructure in the rat.
13 Citations1978Wehman Hj, Fima Lifshitz +1 more
Increased populations of nonspecific enteric bacteria in the lumen of the upper small intestine and ultrastructural abnormalities in the absorptive epithelial cells, including increased numbers of lysosomal vacular structures, fused microvilli and dilated endoplasmic reticulum are found.
Journal of Pharmacology and Experimental TherapeuticsThe influence of mecamylamine on contractions induced by different agonists and on the role of calcium ions in the isolated rabbit aorta.
12 Citations1976Courtland Robinson, B. V. Rama Sastry
The exposure of helically cut strips of rabbit aorta to mecamylamine for 5 minutes blocked the histamine-induced contractions completely and reduced those induced by potassium without affecting contractions induced by norepinephrine or acetylcholine, while Procaine antagonizes the effects of NE, histamine and acetyl choline by affecting, at least partially, the firmly bound calcium stores.
Acta Neurologica ScandinavicaReduction of bladder contractility after alpha-adrenergic blockade and after ganglionic blockade
12 Citations2009Paul E. Kaplan, John B. Nanninga
Seven spinal cord injured patients were evaluated with cystometry bladder, electromyography, and pressure profiles of the external urethral sphincter before and after phenoxybenzamine and mecamylamine administration, finding that both drugs reduced the contractility of the bladder.
Cellular and Molecular Life SciencesThe effect of small doses of mecamylamine on shuttlebox behavior in the guinea-pig
11 Citations1973Peter Driscoll, K. Bättig
Für die Verminderung der Vermeidungsleistung innerhalb einer Sitzung, die für diese Spezies charakteristisch ist, war die gemessene Reaktionslatenz der empfindlichste Indikator eine signifikante Depression des «Shuttlebox»-Verhaltens beobachtet.
Journal of Pharmacy and PharmacologyAntagonism of anti-inflammatory drugs on bradykinin-induced increase of capillary permeability
11 Citations1967E. Arrigoni Martelli
The bradykinin‐induced increase of capillary permeability in the rat paw was not affected to any extent by urethane anaesthesia nor by mecamylamine, papaverine, reserpine or chlorothiazide.
Journal of Pharmacology and Experimental TherapeuticsPotentiation of vasoactive drugs by ganglionic blocking agents
10 Citations1961B K Lum, P.L. Rashleigh
It is concluded that potentiation of the pressor response to epinephrine and other drugs by TEA and mecamylamine in intact animals is due in part to a direct action of these agents on vascular effector cells, an action which is independent of ganglionic blockade.
British Journal of Pharmacology and ChemotherapyACTIONS OF MECAMYLAMINE, DIMECAMINE, PEMPIDINE AND THEIR TWO QUATERNARY METHO‐SALTS AT THE NEUROMUSCULAR JUNCTION
9 Citations1964J. G. Blackman, Chittaranjan Ray
It was concluded that the active component of each amine was the cation acting extracellularly, and pempidine methiodide appeared both to enhance the release of acetylcholine from motor-nerve terminals and to cause postsynaptic block.
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